O-GLYCOSIDASE

Base Information

• Chemical Name: O-GLYCOSIDASE
• CAS No.: 9032-92-2
• Molecular Weight: 0

Synonyms:

Chemical Property of O-GLYCOSIDASE

Chemical Property:

• Storage Temp.: 2-8°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

O-Glycosidase from Streptococcus pneumoniae recombinant, expressed in E. coli, buffered aqueous solution ^*data from reagent suppliers

Safty Information:

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MSDS Files:

Useful:

• Uses: O-Glycosidase is used to release the Gal-β(1,3)-GaINAc unit from O-glycans (glycoproteins or glycopeptides). Bindings to serine as well as to threonine are hydrolyzed. Substituents at the disaccharide (e.g., sialic acid) prevent the hydrolysis and, therefore, have to be removed chemically or enzymatically (e.g., with neuraminidase from Arthrobacter or from Vibrio cholerae).O-Glycosidase has been used to selectively deglycosylated chondroitin sulfate proteoglycans (CSPGs).

Refernces

Enantiospecific synthesis of polyhydroxylated indolizidines related to castanospermine: (6R, 7S, 8aR) - 6,7-dihydroxyindolizidine and (6R, 7R, 8S, 8aR) - 6,7,8-trihydroxyindolizidine

10.1016/S0040-4020(01)89805-7

The study reports the enantiospecific syntheses of (6R,7S,8aR)-6,7-dihydroxyindolizidine (3) and (6R,7R,8S,8aR)-6,7,8-trihydroxyindolizidine (4) from methyl 2-azido-4,6-O-benzylidene-2-deoxy-a-D-altropyranoside (7). These polyhydroxylated indolizidines are important due to their inhibitory action against various glycosidases, cancer metastasis, and HIV replication. The synthesis involves constructing hydroxylated piperidines and using key intermediates like methyl 2,6-benzyloxycarbonylimino-2,6-dideoxy-a-D-altropyranoside (6). The study explores different synthetic routes, including the use of dithioacetals and Wittig reactions, to achieve the desired indolizidines. The synthesized compounds were tested against a range of enzymes from human liver extracts, revealing that dihydroxy-indolizidine (3) enhances the activity of some enzymes while acting as a weak inhibitor of others, and trihydroxy-indolizidine (4) functions as a weak inhibitor of certain glycosidases.

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