3',4'-Dihydroxyflavonol

Base Information

Chemical Name:3',4'-Dihydroxyflavonol
CAS No.:6068-78-6
Molecular Formula:C15H10 O5
Molecular Weight:270.241
Hs Code.:2914501900
European Community (EC) Number:804-231-5
UNII:R1I1R1C88V
DSSTox Substance ID:DTXSID40209494
Nikkaji Number:J923G
Wikidata:Q27287663
Metabolomics Workbench ID:74717
ChEMBL ID:CHEMBL122701
Mol file:6068-78-6.mol

Synonyms:3',4'-dihydroxyflavonol;3,3',4'-trihydroxyflavone

Suppliers and Price of 3',4'-Dihydroxyflavonol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
3'',4''-Dihydroxyflavonol
500mg
$ 1260.00

TRC
3'',4''-Dihydroxyflavonol
250mg
$ 730.00

Sigma-Aldrich
3’,4’-Dihydroxyflavonol ≥98% (HPLC)
25mg
$ 275.00

Sigma-Aldrich
3’,4’-Dihydroxyflavonol ≥98% (HPLC)
5mg
$ 70.40

Labseeker
2',3'-DIMETHOXY-3-HYDROXYFLAVONE 97
25g
$ 1925.00

Total 5 raw suppliers

Chemical Property of 3',4'-Dihydroxyflavonol

Chemical Property:

Vapor Pressure:3.52E-11mmHg at 25°C
Melting Point:301-303 °C (decomp)(Solv: methanol (67-56-1))
Boiling Point:508.9°C at 760 mmHg
PKA:8.58±0.20(Predicted)
Flash Point:198°C
PSA：90.90000
Density:1.579g/cm³
LogP:2.57680
Storage Temp.:2-8°C
Solubility.:DMSO: >15mg/mL
XLogP3:2.7
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:1
Exact Mass:270.05282342
Heavy Atom Count:20
Complexity:430

Purity/Quality:

97% ^*data from raw suppliers

3'',4''-Dihydroxyflavonol ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:T
Statements: 25
Safety Statements: 45

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC=C2C(=C1)C(=O)C(=C(O2)C3=CC(=C(C=C3)O)O)O
Uses 3'',4''-Dihydroxyflavonol is a synthetic flavonol shown to be able to significantly improve endothelium-dependent relaxation in the presence of those oxygen radical generators in rats.

Technology Process of 3',4'-Dihydroxyflavonol

There total 16 articles about 3',4'-Dihydroxyflavonol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 44.0%

: 6889-80-1
2-(3,4-dimethoxyphenyl)-3-hydroxy-4H-chromen-4-one

: 6068-78-6
3,3',4'-trihydroxyflavone

Guidance literature:: With hydrogen iodide; Heating;
DOI:10.1002/1521-4184(20007)333:7<205::AID-ARDP205>3.0.CO;2-Y

Reference yield:

: 118-93-4,104809-67-8
o-hydroxyacetophenone

: 6068-78-6
3,3',4'-trihydroxyflavone

Guidance literature:: Multi-step reaction with 3 steps

1: 40 percent aq. KOH / dioxane; ethanol / 66 h / 20 °C

2: 5.4 percent aq. NaOH; 35 percent aq. H₂O₂ / dioxane; ethanol / 0 - 20 °C

3: 69 percent / 36 percent aq. HCl; glacial acetic acid / 100 °C

With hydrogenchloride; potassium hydroxide; sodium hydroxide; dihydrogen peroxide; acetic acid; In 1,4-dioxane; ethanol; 1: Condensation / 2: Algar-Flynn-Oyamada reaction / 3: debenzylation;
DOI:10.1021/jm000951n

Reference yield:

: 5447-02-9
3,4-dibenzyloxybenzaldehyde

: 6068-78-6
3,3',4'-trihydroxyflavone

Guidance literature:: Multi-step reaction with 3 steps

1: 40 percent aq. KOH / dioxane; ethanol / 66 h / 20 °C

2: 5.4 percent aq. NaOH; 35 percent aq. H₂O₂ / dioxane; ethanol / 0 - 20 °C

3: 69 percent / 36 percent aq. HCl; glacial acetic acid / 100 °C

With hydrogenchloride; potassium hydroxide; sodium hydroxide; dihydrogen peroxide; acetic acid; In 1,4-dioxane; ethanol; 1: Condensation / 2: Algar-Flynn-Oyamada reaction / 3: debenzylation;
DOI:10.1021/jm000951n