(2S)-N-benzyl-2-[(2S)-2-(2-hydroxyacetyl)pyrrolidine-1-carbonyl]pyrrolidine-1-carboxamide

Base Information

• Chemical Name: (2S)-N-benzyl-2-[(2S)-2-(2-hydroxyacetyl)pyrrolidine-1-carbonyl]pyrrolidine-1-carboxamide
• CAS No.: 162203-65-8
• Molecular Formula: C19H25 N3 O4
• Molecular Weight: 359.425
• Mol file: 162203-65-8.mol

Synonyms:1-Pyrrolidinecarboxamide,2-[[2-(hydroxyacetyl)-1-pyrrolidinyl]carbonyl]-N-(phenylmethyl)-, [S-(R*,R*)]-;JTP 4819

Chemical Property of (2S)-N-benzyl-2-[(2S)-2-(2-hydroxyacetyl)pyrrolidine-1-carbonyl]pyrrolidine-1-carboxamide

Chemical Property:

• Vapor Pressure: 4.68E-19mmHg at 25°C
• Boiling Point: 673.5°Cat760mmHg
• Flash Point: 361.1°C
• PSA: 93.44000
• Density: 1.3g/cm³
• LogP: 0.99320

Purity/Quality:

99% ^*data from raw suppliers

JTP 4819 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (2S)-N-benzyl-2-[(2S)-2-(2-hydroxyacetyl)pyrrolidine-1-carbonyl]pyrrolidine-1-carboxamide

There total 3 articles about (2S)-N-benzyl-2-[(2S)-2-(2-hydroxyacetyl)pyrrolidine-1-carbonyl]pyrrolidine-1-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

active charcoal + (S)-2-[[(S)-2-(acetoxyacetyl)-1-pyrrolidinyl]carbonyl]-N-(phenylmethyl)-1-pyrrolidinecarboxamide → JTP 4819 (162203-65-8)

Guidance literature:

With potassium carbonate; In water-methanol; dichloromethane; ethyl acetate;

Reference yield:

(S)-N-(Phenylmethyl)-2-[[(S)-2-[(phenylmethyloxy)acetyl]-1-pyrrolidinyl]carbonyl]-1-pyrrolidinecarboxamide (153451-01-5) → JTP 4819 (162203-65-8)

Guidance literature:

With acetic acid; In methanol; water;

Reference yield:

ammonium cerium (III) nitrate + (S)-2-[[(S)-2-[(p-Methoxyphenoxy)acetyl]-1-pyrrolidinyl]carbonyl]-N-(phenylmethyl)-1-pyrrolidinecarboxamide → JTP 4819 (162203-65-8)

Guidance literature:

With pyridine; In water; acetonitrile;

upstream raw materials:

(S)-N-(Phenylmethyl)-2-[[(S)-2-[(phenylmethyloxy)acetyl]-1-pyrrolidinyl]carbonyl]-1-pyrrolidinecarboxamide