Technology Process of Pyrazolo[3,4-d]azepine-6(2H)-carboxylic acid,
4,5,7,8-tetrahydro-2,3-diphenyl-, 1,1-dimethylethyl ester
There total 4 articles about Pyrazolo[3,4-d]azepine-6(2H)-carboxylic acid,
4,5,7,8-tetrahydro-2,3-diphenyl-, 1,1-dimethylethyl ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
potassium phosphate;
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride;
In
1,4-dioxane;
at 80 - 100 ℃;
for 15h;
- Guidance literature:
-
Multi-step reaction with 3 steps
1: triethylamine / 4 h / 80 °C / Inert atmosphere
2: N-ethyl-N,N-diisopropylamine / dichloromethane / 3 h / Reflux; Inert atmosphere
3: tetrabutylammomium bromide; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; 1,1'-bis-(diphenylphosphino)ferrocene; sodium carbonate; potassium phosphate / toluene; water; 1,4-dioxane / 100 °C / Inert atmosphere
With
1,1'-bis-(diphenylphosphino)ferrocene; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium phosphate; tetrabutylammomium bromide; sodium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine;
In
1,4-dioxane; dichloromethane; water; toluene;
3: |Suzuki-Miyaura Coupling;
DOI:10.1016/j.bmcl.2020.127669
- Guidance literature:
-
Multi-step reaction with 4 steps
1: boron trifluoride diethyl etherate / diethyl ether / 1 h / -5 - 0 °C / Inert atmosphere
2: triethylamine / 4 h / 80 °C / Inert atmosphere
3: N-ethyl-N,N-diisopropylamine / dichloromethane / 3 h / Reflux; Inert atmosphere
4: tetrabutylammomium bromide; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; 1,1'-bis-(diphenylphosphino)ferrocene; sodium carbonate; potassium phosphate / toluene; water; 1,4-dioxane / 100 °C / Inert atmosphere
With
1,1'-bis-(diphenylphosphino)ferrocene; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium phosphate; boron trifluoride diethyl etherate; tetrabutylammomium bromide; sodium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine;
In
1,4-dioxane; diethyl ether; dichloromethane; water; toluene;
4: |Suzuki-Miyaura Coupling;
DOI:10.1016/j.bmcl.2020.127669
