Technology Process of Benzeneethanamine, b-(difluoromethylene)-
There total 5 articles about Benzeneethanamine, b-(difluoromethylene)- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 3 steps
1: diisobutylaluminum hydride / tetrahydrofuran; hexane / 3 h / -78 - 5 °C
2: 62 percent / Ph3P; diethyl azodicarboxylate / tetrahydrofuran / 0 - 20 °C
3: hydrazine hydrate / methanol / 3 h / Heating
With
diisobutylaluminium hydride; hydrazine hydrate; triphenylphosphine; diethylazodicarboxylate;
In
tetrahydrofuran; methanol; hexane;
2: Mitsunobu reaction;
DOI:10.1016/j.bmc.2005.09.065
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 62 percent / Ph3P; diethyl azodicarboxylate / tetrahydrofuran / 0 - 20 °C
2: hydrazine hydrate / methanol / 3 h / Heating
With
hydrazine hydrate; triphenylphosphine; diethylazodicarboxylate;
In
tetrahydrofuran; methanol;
1: Mitsunobu reaction;
DOI:10.1016/j.bmc.2005.09.065
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: NaH / tetrahydrofuran / 0 °C
1.2: tetrahydrofuran / 120 h / 20 °C
2.1: 110 °C
3.1: diisobutylaluminum hydride / tetrahydrofuran; hexane / 3 h / -78 - 5 °C
4.1: 62 percent / Ph3P; diethyl azodicarboxylate / tetrahydrofuran / 0 - 20 °C
5.1: hydrazine hydrate / methanol / 3 h / Heating
With
sodium hydride; diisobutylaluminium hydride; hydrazine hydrate; triphenylphosphine; diethylazodicarboxylate;
In
tetrahydrofuran; methanol; hexane;
4.1: Mitsunobu reaction;
DOI:10.1016/j.bmc.2005.09.065
