Ethyl 4,5-dichloro-1-methyl-6-oxo-1,6-dihydropyridine-3-carboxylate

Base Information

Chemical Name:Ethyl 4,5-dichloro-1-methyl-6-oxo-1,6-dihydropyridine-3-carboxylate
CAS No.:853105-72-3
Molecular Formula:C₉H₉Cl₂NO₃
Molecular Weight:250.081
Hs Code.:2933399090
European Community (EC) Number:692-452-6
DSSTox Substance ID:DTXSID60470629
Wikidata:Q82298782
Mol file:853105-72-3.mol

Synonyms:ethyl 4,5-dichloro-1-methyl-6-oxo-1,6-dihydropyridine-3-carboxylate;853105-72-3;ethyl 4,5-dichloro-1-methyl-6-oxopyridine-3-carboxylate;SCHEMBL388418;DTXSID60470629;XVWBNMBDIHGHCA-UHFFFAOYSA-N;MFCD09031524;AKOS015965510;MF-0737;CS-0330896;FT-0684587;J-520949;ethyl4,5-dichloro-1-methyl-6-oxo-1,6-dihydropyridine-3-carboxylate;4,5-dichloro-1-methyl-6-oxo-1,6-dihydropyridine-3-carboxylic acid ethyl ester

Suppliers and Price of Ethyl 4,5-dichloro-1-methyl-6-oxo-1,6-dihydropyridine-3-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Matrix Scientific
Ethyl 4,5-dichloro-1-methyl-6-oxo-1,6-dihydropyridine-3-carboxylate
1g
$ 405.00

Matrix Scientific
Ethyl 4,5-dichloro-1-methyl-6-oxo-1,6-dihydropyridine-3-carboxylate
500mg
$ 263.00

Crysdot
Ethyl4,5-dichloro-1-methyl-6-oxo-1,6-dihydropyridine-3-carboxylate 95+%
1g
$ 401.00

American Custom Chemicals Corporation
4,5-DICHLORO-1-METHYL-6-OXO-1,6-DIHYDRO-PYRIDINE-3-CARBOXYLIC ACID ETHYL ESTER 95.00%
5MG
$ 500.91

AK Scientific
Ethyl4,5-dichloro-1-methyl-6-oxo-1,6-dihydropyridine-3-carboxylate
500mg
$ 405.00

Total 3 raw suppliers

Chemical Property of Ethyl 4,5-dichloro-1-methyl-6-oxo-1,6-dihydropyridine-3-carboxylate

Chemical Property:

PSA：48.30000
LogP:1.86880
XLogP3:1.5
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:3
Exact Mass:248.9959485
Heavy Atom Count:15
Complexity:374

Purity/Quality:

98%min ^*data from raw suppliers

Ethyl 4,5-dichloro-1-methyl-6-oxo-1,6-dihydropyridine-3-carboxylate ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCOC(=O)C1=CN(C(=O)C(=C1Cl)Cl)C

Technology Process of Ethyl 4,5-dichloro-1-methyl-6-oxo-1,6-dihydropyridine-3-carboxylate

There total 3 articles about Ethyl 4,5-dichloro-1-methyl-6-oxo-1,6-dihydropyridine-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 821791-58-6
ethyl 4-chloro-1-methyl-6-oxo-1,6-dihydropyridine-3-carboxylate

: 853105-72-3
ethyl 4,5-dichloro-1-methyl-6-oxo-1,6-dihydropyridine-3-carboxylate

Guidance literature:: With N-chloro-succinimide; In N,N-dimethyl-formamide; at 20 ℃; for 1h;

Reference yield:

: 853105-37-0
ethyl 4-hydroxy-1-methyl-6-oxo-1,6-dihydropyridine-3-carboxylate

: 853105-72-3
ethyl 4,5-dichloro-1-methyl-6-oxo-1,6-dihydropyridine-3-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: POCl₃; Et₃N / 16 h

2: NCS / dimethylformamide / 1 h / 20 °C

With N-chloro-succinimide; triethylamine; trichlorophosphate; In N,N-dimethyl-formamide;
DOI:10.1021/jm050834y

Reference yield:

: 105-50-0
diethyl 1,3-acetonedicarboxylate

: 853105-72-3
ethyl 4,5-dichloro-1-methyl-6-oxo-1,6-dihydropyridine-3-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: Ac₂O / 1 h / 135 °C

1.2: 54 percent / H₂O / 16 h / 20 °C

2.1: POCl₃; Et₃N / 16 h

3.1: NCS / dimethylformamide / 1 h / 20 °C

With N-chloro-succinimide; acetic anhydride; triethylamine; trichlorophosphate; In N,N-dimethyl-formamide;
DOI:10.1021/jm050834y