4-((4-broMo-2-fluorophenyl)aMino)-5-fluoro-1-Methyl-6-oxo-1,6-dihydropyridine-3-carboxylic acid

Base Information

Chemical Name:4-((4-broMo-2-fluorophenyl)aMino)-5-fluoro-1-Methyl-6-oxo-1,6-dihydropyridine-3-carboxylic acid
CAS No.:853105-98-3
Molecular Formula:C13H9BrF2N2O3
Molecular Weight:359.127
Hs Code.:
Mol file:853105-98-3.mol

Synonyms:4-(4-Bromo-2-fluoro-phenylamino)-5-fluoro-1-methyl-6-oxo-1,6-dihydro-pyridine-3-carboxylic acid;

Suppliers and Price of 4-((4-broMo-2-fluorophenyl)aMino)-5-fluoro-1-Methyl-6-oxo-1,6-dihydropyridine-3-carboxylic acid

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4-((4-broMo-2-fluorophenyl)aMino)-5-fluoro-1-Methyl-6-oxo-1,6-dihydropyridine-3-carboxylic acid

Chemical Property:

PSA：71.33000
LogP:2.94080

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 4-((4-broMo-2-fluorophenyl)aMino)-5-fluoro-1-Methyl-6-oxo-1,6-dihydropyridine-3-carboxylic acid

There total 5 articles about 4-((4-broMo-2-fluorophenyl)aMino)-5-fluoro-1-Methyl-6-oxo-1,6-dihydropyridine-3-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 853105-92-7
4-chloro-5-fluoro-1-methyl-6-oxo-1,6-dihydropyridine-3-carboxylic acid

: 367-24-8
4-bromo-2-fluoroaniline

: 853105-98-3
4-(4-bromo-2-fluorophenylamino)-5-fluoro-1-methyl-6-oxo-1,6-dihydropyridine-3-carboxylic acid

Guidance literature:: 4-bromo-2-fluoroaniline; With lithium diisopropyl amide; In tetrahydrofuran; hexane; at -78 ℃; for 0.166667h;

4-chloro-5-fluoro-1-methyl-6-oxo-1,6-dihydropyridine-3-carboxylic acid; In tetrahydrofuran; hexane; at -78 - 20 ℃; for 17.5h;
DOI:10.1021/jm050834y

Reference yield:

: 821791-58-6
ethyl 4-chloro-1-methyl-6-oxo-1,6-dihydropyridine-3-carboxylate

: 853105-98-3
4-(4-bromo-2-fluorophenylamino)-5-fluoro-1-methyl-6-oxo-1,6-dihydropyridine-3-carboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: [1-chloromethyl-4-F-1,4-diazoniabicyclo[2.2.2]octane]*(BF₄)2 / acetonitrile / 1 h / 85 °C

2.1: aq. LiOH / tetrahydrofuran; methanol / 1 h / 20 °C

3.1: LDA / tetrahydrofuran; hexane / 0.17 h / -78 °C

3.2: tetrahydrofuran; hexane / 17.5 h / -78 - 20 °C

With lithium hydroxide; Selectfluor; lithium diisopropyl amide; In tetrahydrofuran; methanol; hexane; acetonitrile;
DOI:10.1021/jm050834y

Reference yield:

: 853105-37-0
ethyl 4-hydroxy-1-methyl-6-oxo-1,6-dihydropyridine-3-carboxylate

: 853105-98-3
4-(4-bromo-2-fluorophenylamino)-5-fluoro-1-methyl-6-oxo-1,6-dihydropyridine-3-carboxylic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: POCl₃; Et₃N / 16 h

2.1: [1-chloromethyl-4-F-1,4-diazoniabicyclo[2.2.2]octane]*(BF₄)2 / acetonitrile / 1 h / 85 °C

3.1: aq. LiOH / tetrahydrofuran; methanol / 1 h / 20 °C

4.1: LDA / tetrahydrofuran; hexane / 0.17 h / -78 °C

4.2: tetrahydrofuran; hexane / 17.5 h / -78 - 20 °C

With lithium hydroxide; Selectfluor; triethylamine; lithium diisopropyl amide; trichlorophosphate; In tetrahydrofuran; methanol; hexane; acetonitrile;
DOI:10.1021/jm050834y