[4-AMino-2-(trifluoroMethyl)phenyl](4-Methyl-1-piperazinyl)Metha

Base Information

• Chemical Name: [4-AMino-2-(trifluoroMethyl)phenyl](4-Methyl-1-piperazinyl)Metha
• CAS No.: 853297-04-8
• Molecular Formula: C13H16F3N3O
• Molecular Weight: 287.285
• Hs Code.: 2933599090
• Mol file: 853297-04-8.mol

Synonyms:[4-Amino-2-(trifluoromethyl)phenyl](4-methyl-1-piperazinyl)methanone;(4-amino-2-trifluoromethyl-phenyl)-(4-methylpiperazin-1-yl)-methanone;Piperazine,1-[4-amino-2-(trifluoromethyl)benzoyl]-4-methyl;4-[(4-methylpiperazin-1-yl)carbonyl]-3-(trifluoro-methyl)aniline;

Chemical Property of [4-AMino-2-(trifluoroMethyl)phenyl](4-Methyl-1-piperazinyl)Metha

Chemical Property:

• PSA: 49.57000
• LogP: 2.13220
• Storage Temp.: 2-8°C(protect from light)

Purity/Quality:

97% ^*data from raw suppliers

[4-Amino-2-(trifluoromethyl)phenyl](4-methyl-1-piperazinyl)methanone ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of [4-AMino-2-(trifluoroMethyl)phenyl](4-Methyl-1-piperazinyl)Metha

There total 6 articles about [4-AMino-2-(trifluoroMethyl)phenyl](4-Methyl-1-piperazinyl)Metha which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

(4-methylpiperazin-1-yl)-[4-nitro-2-(trifluoromethyl)phenyl]methanone (853297-03-7) → [4-amino-2-(trifluoromethyl)phenyl]-(4-methylpiperazin-1-yl)methanone (853297-04-8)

Guidance literature:

With palladium 10% on activated carbon; ammonium formate; In methanol; water; at 20 ℃; for 2h; Inert atmosphere;

Reference yield: 86.0%

→ [4-amino-2-(trifluoromethyl)phenyl]-(4-methylpiperazin-1-yl)methanone (853297-04-8)

Guidance literature:

With potassium carbonate; In methanol; water;

Reference yield: 76.5%

1-methyl-piperazine (109-01-3) + 4-amino-2-(trifluoromethyl)benzoic acid (393-06-6) → [4-amino-2-(trifluoromethyl)phenyl]-(4-methylpiperazin-1-yl)methanone (853297-04-8)

Guidance literature:

With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at -5 - 20 ℃;

upstream raw materials:

(4-methylpiperazin-1-yl)-[4-nitro-2-(trifluoromethyl)phenyl]methanone

2-trifluoromethylbenzoic acid

4-nitro-2-(trifluoromethyl)benzoic acid

3-trifluoromethyl-4-nitrobenzoyl chloride

Downstream raw materials:

4-(4-methylpiperazin-1-ylmethyl)-3-trifluoromethylaniline

N-[4-(6-chloro-pyrimidin-4-yloxy)-phenyl]-N'-[4-(4-methylpiperazin-1-ylmethyl)-3-trifluoromethyl-phenyl]-urea

Refernces

• 1、 -. "1H-1,8- NAPHTHYRIDIN-2ONES AS ANTI PROLIFERATIVE COMPOUNDS". Page/Page column 18; 19. . Retrieved 2015/12/30.
• 2、 Oguro, Yuya,Miyamoto, Naoki,Takagi, Terufumi,Okada, Kengo,Awazu, Yoshiko,Miki, Hiroshi,Hori, Akira,Kamiyama, Keiji,Imamura, Shinichi. "N-Phenyl-N′-[4-(5H-pyrrolo[3,2-d]pyrimidin-4-yloxy)phenyl]ureas as novel inhibitors of VEGFR and FGFR kinases". experimental part. p. 7150 - 7163. Retrieved 2010/11/20.