2,4-Pyrimidinediamine,5-(bromomethyl)-, hydrobromide (1:1)

Base Information

• Chemical Name: 2,4-Pyrimidinediamine,5-(bromomethyl)-, hydrobromide (1:1)
• CAS No.: 20781-09-3
• Molecular Formula: BrH*C₅H₇BrN₄
• Molecular Weight: 283.953
• Mol file: 20781-09-3.mol

Synonyms:2,4-Pyrimidinediamine,5-(bromomethyl)-, monohydrobromide (9CI); Pyrimidine, 2,4-diamino-5-(bromomethyl)-,monohydrobromide (8CI)

Chemical Property of 2,4-Pyrimidinediamine,5-(bromomethyl)-, hydrobromide (1:1)

Chemical Property:

• Boiling Point: 452.8°Cat760mmHg
• Flash Point: 227.7°C
• Density: 1.846g/cm³

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2,4-Pyrimidinediamine,5-(bromomethyl)-, hydrobromide (1:1)

There total 4 articles about 2,4-Pyrimidinediamine,5-(bromomethyl)-, hydrobromide (1:1) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,4-diamino-5-hydroxymethyl-pyrimidine (42310-45-2) → 5-(bromomethyl)pyrimidine-2,4-diamine hydrobromide (20781-09-3)

Guidance literature:

With hydrogen bromide; acetic acid; for 3h; Heating;

DOI:10.1021/jm030931w

Reference yield:

2,4-diamino-pyrimidine-5-carbonitrile (16462-27-4) → 5-(bromomethyl)pyrimidine-2,4-diamine hydrobromide (20781-09-3)

Guidance literature:

Multi-step reaction with 3 steps

1: H₂; aq. HCl / Pd/C / 3 h / 60 °C / 3150.25 Torr

2: aq. NaBH₄

3: aq. HBr; AcOH / 3 h / Heating

With hydrogenchloride; sodium tetrahydroborate; hydrogen bromide; hydrogen; acetic acid; palladium on activated charcoal;

DOI:10.1021/jm030931w

Reference yield:

2,4-diamino-5-pyrimidinecarboxaldehyde (20781-06-0) → 5-(bromomethyl)pyrimidine-2,4-diamine hydrobromide (20781-09-3)

Guidance literature:

Multi-step reaction with 2 steps

1: aq. NaBH₄

2: aq. HBr; AcOH / 3 h / Heating

With sodium tetrahydroborate; hydrogen bromide; acetic acid;

DOI:10.1021/jm030931w

upstream raw materials:

2,4-diamino-5-hydroxymethyl-pyrimidine

2,4-diamino-5-pyrimidinecarboxaldehyde

2,4-diamino-pyrimidine-5-carbonitrile

Downstream raw materials:

1-[(2,4-diamino-5-pyrimidinyl)methyl]pyridinium bromide monohydrobromide