Trofinetide

Base Information

Chemical Name:Trofinetide
CAS No.:853400-76-7
Molecular Formula:C₁₃H₂₁N₃O₆
Molecular Weight:315.326
Hs Code.:
European Community (EC) Number:863-268-5
UNII:Z2ME8F52QL
ChEMBL ID:CHEMBL197084
DSSTox Substance ID:DTXSID101336041
Metabolomics Workbench ID:149616
NCI Thesaurus Code:C152757
Nikkaji Number:J2.238.146F
RXCUI:2632852
Wikidata:Q27294917
Wikipedia:Trofinetide

Synonyms:daybue;glycyl-2-methyl-l-prolyl-l-glutamic acid;glycyl-l-2-methylprolyl-l-glutamic acid;NNZ 2566;NNZ-2566;NNZ2566;trofinetide

Suppliers and Price of Trofinetide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 21 raw suppliers

Chemical Property of Trofinetide

Chemical Property:

XLogP3:-3.9
Hydrogen Bond Donor Count:4
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:7
Exact Mass:315.14303540
Heavy Atom Count:22
Complexity:480

Purity/Quality:: 99%, ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC1(CCCN1C(=O)CN)C(=O)NC(CCC(=O)O)C(=O)O
Isomeric SMILES:C[C@]1(CCCN1C(=O)CN)C(=O)N[C@@H](CCC(=O)O)C(=O)O
Recent ClinicalTrials:Open-Label Extension Study of Trofinetide for Rett Syndrome

Technology Process of Trofinetide

There total 14 articles about Trofinetide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: Z-Gly-MePro-Glu-OH

: 853400-76-7
glycyl-L-2-methylprolyl-L-glutamic acid

Guidance literature:: With palladium on activated charcoal; hydrogen; In water; ethyl acetate; at 20 ℃; Solvent; Temperature; Reagent/catalyst;

Reference yield: 86.0%

: 869001-94-5
dibenzyl N-benzyloxycarbonyl-glycyl-L-2-methylprolyl-L-glutamate

: 853400-76-7
glycyl-L-2-methylprolyl-L-glutamic acid

Guidance literature:: With hydrogen; palladium on activated charcoal; In methanol; water; at 20 ℃; for 23h;
DOI:10.1016/j.tet.2005.08.026

Reference yield:

: 869001-94-5
dibenzyl N-benzyloxycarbonyl-glycyl-L-2-methylprolyl-L-glutamate

: 853400-76-7
glycyl-L-2-methylprolyl-L-glutamic acid

: 914249-36-8
C₁₄H₂₃N₃O₆

Guidance literature:: With palladium 10% on activated carbon; hydrogen; In methanol; water; at 20 ℃; for 23h; Overall yield = 86 %; Overall yield = 0.27 g; Darkness;