Oxiranemethanol, 3-cyclohexyl-

Base Information

• Chemical Name: Oxiranemethanol, 3-cyclohexyl-
• CAS No.: 85531-72-2
• Molecular Formula: C9H16O2
• Molecular Weight: 156.225
• Mol file: 85531-72-2.mol

Synonyms:

Chemical Property of Oxiranemethanol, 3-cyclohexyl-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Oxiranemethanol, 3-cyclohexyl-

There total 6 articles about Oxiranemethanol, 3-cyclohexyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

cis S-tert-Butyl 3-cyclohexyloxirane-2-carbothioate (142528-81-2,142528-82-3) → cis 2-Hydroxymethyl-3-cyclohexyloxirane (85531-72-2,86990-94-5,99883-81-5,111902-61-5,115362-12-4,127851-94-9,142562-98-9)

Guidance literature:

With sodium tetrahydroborate; In ethanol; for 8h; Ambient temperature; or LiAlH₄/ether, -78 deg C, 1 h;

Reference yield: 60.0%

(E)-3-cyclohexyl-2-propen-1-ol (42134-55-4,132350-24-4,114096-03-6) → 3-cyclohexyl-2,3-epoxypropan-1-ol (85531-72-2)

Guidance literature:

With sodium hydrogencarbonate; 3-chloro-benzenecarboperoxoic acid; In dichloromethane; at 0 ℃; for 2.5h; Inert atmosphere;

DOI:10.1039/d0ob01226b

Reference yield:

(E)-3-cyclohexyl-2-propen-1-ol (42134-55-4,132350-24-4,114096-03-6) → 3-cyclohexyloxirane-2-carbaldehyde (1414943-27-3,445387-92-8) + 3-cyclohexyl-2,3-epoxypropan-1-ol (85531-72-2)

Guidance literature:

(E)-3-cyclohexyl-2-propen-1-ol; With C₇₆H₅₆N₂O₂; niobium(V) isopropoxide; In chloroform; sodium chloride; at 40 ℃; for 0.5h;

With dihydrogen peroxide; In chloroform; water; sodium chloride; at 40 ℃; enantioselective reaction;

DOI:10.1021/ja100795k

upstream raw materials:

(E)-3-cyclohexyl-2-propen-1-ol

cyclohexanecarbaldehyde

(E)-3-cyclohexyl-acrylic acid ethyl ester

cis S-tert-Butyl 3-cyclohexyloxirane-2-carbothioate

Downstream raw materials:

3-cyclohexylpropane-1,2-diol

1-cyclohexyl-1,3-propanediol

(1S,2R)-2-Azido-1-cyclohexyl-propane-1,3-diol

(2R*,3R*)-3-azido-3-cyclohexylpropane-1,2-diol

Refernces

• 1、 Righi, Giuliana,Bovicelli, Paolo,Tirotta, Ilaria. "New one-pot procedure for the synthesis of diprotected amino alcohols from unprotected vinyl aziridines". . p. 6439 - 6442. Retrieved 2013/11/19.
• 2、 Egami, Hiromichi,Oguma, Takuya,Katsuki, Tsutomu. "Oxidation catalysis of Nb(salan) complexes: Asymmetric epoxidation of allylic alcohols using aqueous hydrogen peroxide as an oxidant". scheme or table. p. 5886 - 5895. Retrieved 2010/07/05.