4-{6-[(3R)-1-Aza-bicyclo[2.2.2]oct-3-yloxy]-pyridazin-3-yl}-2-nitro-phenylamine

Base Information

Chemical Name:4-{6-[(3R)-1-Aza-bicyclo[2.2.2]oct-3-yloxy]-pyridazin-3-yl}-2-nitro-phenylamine
CAS No.:855738-62-4
Molecular Formula:C17H19N5O3
Molecular Weight:341.37
Hs Code.:
DSSTox Substance ID:DTXSID501141034

Synonyms:SCHEMBL1542238;LYAGMNSMCAELAS-INIZCTEOSA-N;DTXSID501141034;4-{6-[(3R)-1-Aza-bicyclo[2.2.2]oct-3-yloxy]-pyridazin-3-yl}-2-nitro-phenylamine;855738-62-4;4-[6-[(3R)-1-Azabicyclo[2.2.2]oct-3-yloxy]-3-pyridazinyl]-2-nitrobenzenamine

Suppliers and Price of 4-{6-[(3R)-1-Aza-bicyclo[2.2.2]oct-3-yloxy]-pyridazin-3-yl}-2-nitro-phenylamine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4-{6-[(3R)-1-Aza-bicyclo[2.2.2]oct-3-yloxy]-pyridazin-3-yl}-2-nitro-phenylamine

Chemical Property:

XLogP3:2.1
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:3
Exact Mass:341.14878949
Heavy Atom Count:25
Complexity:479

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1CN2CCC1C(C2)OC3=NN=C(C=C3)C4=CC(=C(C=C4)N)[N+](=O)[O-]
Isomeric SMILES:C1CN2CCC1[C@H](C2)OC3=NN=C(C=C3)C4=CC(=C(C=C4)N)[N+](=O)[O-]

Technology Process of 4-{6-[(3R)-1-Aza-bicyclo[2.2.2]oct-3-yloxy]-pyridazin-3-yl}-2-nitro-phenylamine

There total 3 articles about 4-{6-[(3R)-1-Aza-bicyclo[2.2.2]oct-3-yloxy]-pyridazin-3-yl}-2-nitro-phenylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 855738-61-3
{4-{6-[(3R)-1-Aza-bicyclo[2.2.2]oct-3-yloxy]-pyridazin-3-yl}-2-nitro-phenyl}-carbamic Acid tert-butyl Ester

: 855738-62-4
4-{6-[(3R)-1-aza-bicyclo[2.2.2]oct-3-yloxy]-pyridazin-3-yl}-2-nitro-phenylamine

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; ethanol; at 20 ℃; for 1h;

Reference yield: 93.0%

: {4-{6-[(3R)-1-aza-bicyclo[2.2.2]oct-3-yloxy]-pyridazin-3-yl}6,2-nitro-phenyl}-carbamic acid tert-butyl ester

: 855738-62-4
4-{6-[(3R)-1-aza-bicyclo[2.2.2]oct-3-yloxy]-pyridazin-3-yl}-2-nitro-phenylamine

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; ethanol; at 20 ℃; for 1h;

Reference yield:

: 855738-65-7
(R)-N-{4-[6-(1-aza-bicyclo[2.2.2]oct-3-yloxy)-pyridazin-3-yl]-phenyl}-acetamide

: 855738-62-4
4-{6-[(3R)-1-aza-bicyclo[2.2.2]oct-3-yloxy]-pyridazin-3-yl}-2-nitro-phenylamine

Guidance literature:: (R)-N-{4-[6-(1-aza-bicyclo[2.2.2]oct-3-yloxy)-pyridazin-3-yl]-phenyl}-acetamide; With sulfuric acid; nitric acid; In water; at 0 - 4 ℃; for 2h;

With sodium hydroxide; In water; at 0 ℃;