N,N-diethyl-2-hydroxy-5-methoxybenzamide

Base Information

Chemical Name:N,N-diethyl-2-hydroxy-5-methoxybenzamide
CAS No.:85630-32-6
Molecular Formula:C12H17NO3
Molecular Weight:223.272
Hs Code.:
DSSTox Substance ID:DTXSID10513999
Wikidata:Q82374067

Synonyms:N,N-diethyl-2-hydroxy-5-methoxybenzamide;85630-32-6;SCHEMBL487637;DTXSID10513999;AKOS009118636;N,N-diethyl-2-hydroxy-5-methoxy-benzamide

Suppliers and Price of N,N-diethyl-2-hydroxy-5-methoxybenzamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemical Property of N,N-diethyl-2-hydroxy-5-methoxybenzamide

Chemical Property:

XLogP3:2.3
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:4
Exact Mass:223.12084340
Heavy Atom Count:16
Complexity:228

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCN(CC)C(=O)C1=C(C=CC(=C1)OC)O

Technology Process of N,N-diethyl-2-hydroxy-5-methoxybenzamide

There total 6 articles about N,N-diethyl-2-hydroxy-5-methoxybenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 85630-18-8
N,N-diethyl-O-(4-methoxyphenyl)carbamate

: 85630-32-6
N,N-diethyl-2-hydroxy-5-methoxybenzamide

Guidance literature:: With N,N,N,N,-tetramethylethylenediamine; sec.-butyllithium; In tetrahydrofuran; 1.) -78 deg C, 1h, 2.) to room temp., 10 to 12 h;
DOI:10.1021/jo00159a040

Reference yield:

: 150-76-5
4-methoxy-phenol

: 85630-32-6
N,N-diethyl-2-hydroxy-5-methoxybenzamide

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / acetonitrile / 12 h / 20 °C / Inert atmosphere; Reflux

2: lithium diisopropyl amide / tetrahydrofuran / -78 - 20 °C / Inert atmosphere

With potassium carbonate; lithium diisopropyl amide; In tetrahydrofuran; acetonitrile;
DOI:10.1002/anie.201404495

Reference yield:

: 88-10-8
N,N-diethylcarbamyl chloride

: 85630-32-6
N,N-diethyl-2-hydroxy-5-methoxybenzamide

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / acetonitrile / 12 h / 20 °C / Inert atmosphere; Reflux

2: lithium diisopropyl amide / tetrahydrofuran / -78 - 20 °C / Inert atmosphere

With potassium carbonate; lithium diisopropyl amide; In tetrahydrofuran; acetonitrile;
DOI:10.1002/anie.201404495