1H-Pyrrole, 1-ethyl-2-[2-(phenylmethoxy)phenyl]-

Base Information

Chemical Name:1H-Pyrrole, 1-ethyl-2-[2-(phenylmethoxy)phenyl]-
CAS No.:856438-54-5
Molecular Formula:C19H19NO
Molecular Weight:277.366
Hs Code.:

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Chemical Property of 1H-Pyrrole, 1-ethyl-2-[2-(phenylmethoxy)phenyl]-

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Technology Process of 1H-Pyrrole, 1-ethyl-2-[2-(phenylmethoxy)phenyl]-

There total 10 articles about 1H-Pyrrole, 1-ethyl-2-[2-(phenylmethoxy)phenyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 74303-03-0
2-(2-benzyloxyphenyl)-1H-pyrrole

: 80-40-0
ethyl ester of p-toluenesulfonic acid

: 856438-54-5
2-(2-benzyloxy-phenyl)-1-ethyl-1H-pyrrole

Guidance literature:: With sodium hydride; In N,N-dimethyl-formamide; for 1.5h;
DOI:10.1021/ol050897a

Reference yield:

: 1-(2-benzyloxyphenyl)-3-(trimethylsilyl)prop-2-yn-1-ol

: 856438-54-5
2-(2-benzyloxy-phenyl)-1-ethyl-1H-pyrrole

Guidance literature:: Multi-step reaction with 6 steps

1.1: 99 percent / NH₄PF₆ / (dppm)ReOCl₃ / acetonitrile / 4 h / 80 °C

2.1: 89 percent / K₂CO₃ / methanol / 0.5 h / 20 °C

3.1: quinoline; H₂ / Pd/BaSO₄ / ethyl acetate / 0.33 h

3.2: 81 percent / Grubbs second generation ruthenium catalyst / CH₂Cl₂ / 18 h / 20 °C

4.1: 63 percent / 2,3-dichloro-5,6-dicyano-1,4-benzoquinone / toluene / 48 h / 110 °C

5.1: 95 percent / NaOH / ethanol / 0.58 h / 20 °C

6.1: 90 percent / NaH / dimethylformamide / 1.5 h

With quinoline; sodium hydroxide; ammonium hexafluorophosphate; hydrogen; sodium hydride; potassium carbonate; 2,3-dicyano-5,6-dichloro-p-benzoquinone; Pd-BaSO₄; (dppm)ReOCl₃; In methanol; ethanol; ethyl acetate; N,N-dimethyl-formamide; toluene; acetonitrile;
DOI:10.1021/ol050897a

Reference yield:

: 856438-49-8
allyl-[1-(2-benzyloxy-phenyl)-prop-2-ynyl]-carbamic acid methyl ester

: 856438-54-5
2-(2-benzyloxy-phenyl)-1-ethyl-1H-pyrrole

Guidance literature:: Multi-step reaction with 4 steps

1.1: quinoline; H₂ / Pd/BaSO₄ / ethyl acetate / 0.33 h

1.2: 81 percent / Grubbs second generation ruthenium catalyst / CH₂Cl₂ / 18 h / 20 °C

2.1: 63 percent / 2,3-dichloro-5,6-dicyano-1,4-benzoquinone / toluene / 48 h / 110 °C

3.1: 95 percent / NaOH / ethanol / 0.58 h / 20 °C

4.1: 90 percent / NaH / dimethylformamide / 1.5 h

With quinoline; sodium hydroxide; hydrogen; sodium hydride; 2,3-dicyano-5,6-dichloro-p-benzoquinone; Pd-BaSO₄; In ethanol; ethyl acetate; N,N-dimethyl-formamide; toluene;
DOI:10.1021/ol050897a