4-(2-Amino-5-chlorophenyl)-1-benzylpiperidin-4-ol

Base Information

Chemical Name:4-(2-Amino-5-chlorophenyl)-1-benzylpiperidin-4-ol
CAS No.:85732-70-3
Molecular Formula:C18H21ClN2O
Molecular Weight:316.831
Hs Code.:
DSSTox Substance ID:DTXSID40575207
Wikidata:Q82464503

Synonyms:4-(2-Amino-5-chlorophenyl)-1-benzylpiperidin-4-ol;85732-70-3;SCHEMBL73169;DTXSID40575207

Suppliers and Price of 4-(2-Amino-5-chlorophenyl)-1-benzylpiperidin-4-ol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemical Property of 4-(2-Amino-5-chlorophenyl)-1-benzylpiperidin-4-ol

Chemical Property:

XLogP3:2.9
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:3
Exact Mass:316.1342410
Heavy Atom Count:22
Complexity:351

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CN(CCC1(C2=C(C=CC(=C2)Cl)N)O)CC3=CC=CC=C3

Technology Process of 4-(2-Amino-5-chlorophenyl)-1-benzylpiperidin-4-ol

There total 4 articles about 4-(2-Amino-5-chlorophenyl)-1-benzylpiperidin-4-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.4%

: 85732-68-9
1-benzyl-4-hydroxy-4-(2-pivaloylamino-5-chlorophenyl)piperidine

: 85732-70-3
1-benzyl-4-hydroxy-4-(2-amino-5-chlorophenyl)piperidine

Guidance literature:: With sulfuric acid; In water; for 16h; Heating;
DOI:10.1248/cpb.33.1129

Reference yield:

: 85732-68-9
1-benzyl-4-hydroxy-4-(2-pivaloylamino-5-chlorophenyl)piperidine

: 107191-04-8
4-(2-amino-5-chlorophenyl)-1-benzyl-1,2,5,6-tetrahydropyridine

: 85732-70-3
1-benzyl-4-hydroxy-4-(2-amino-5-chlorophenyl)piperidine

Guidance literature:: With hydrogenchloride; In water; butan-1-ol; for 120h; Heating / reflux;

Reference yield:

: 3612-20-2
1-phenylmethyl-4-piperidone

: 85732-70-3
1-benzyl-4-hydroxy-4-(2-amino-5-chlorophenyl)piperidine

Guidance literature:: Multi-step reaction with 2 steps

1: 45.4 percent / n-butyllithium / hexane; tetrahydrofuran / -5 °C

2: 62.4 percent / 3 N H₂SO₄ / H₂O / 16 h / Heating

With n-butyllithium; sulfuric acid; In tetrahydrofuran; hexane; water;
DOI:10.1248/cpb.33.1129