11-Hydroxy-10-methylaporphine

Base Information

• Chemical Name: 11-Hydroxy-10-methylaporphine
• CAS No.: 111635-19-9
• Molecular Formula: C₁₈H₁₉NO
• Molecular Weight: 265.355
• UNII: AUL82ME93B
• DSSTox Substance ID: DTXSID90149699
• Nikkaji Number: J356.049J
• Wikidata: Q83015559
• ChEMBL ID: CHEMBL53510
• Mol file: 111635-19-9.mol

Synonyms:10-methyl-11-hydroxyaporphine;11-HMAPP;11-hydroxy-10-methylaporphine;PM 1000;PM 1000 hydrochloride;PM 1000, (S)-isomer;PM-1000

Chemical Property of 11-Hydroxy-10-methylaporphine

Chemical Property:

• Vapor Pressure: 2.33E-08mmHg at 25°C
• Boiling Point: 440.2°Cat760mmHg
• Flash Point: 233.5°C
• Density: 1.187g/cm³
• XLogP3: 3
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 265.146664230
• Heavy Atom Count: 20
• Complexity: 370

Purity/Quality:

98.5% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=C(C2=C(CC3C4=C(CCN3C)C=CC=C42)C=C1)O
• Isomeric SMILES: CC1=C(C2=C(C[C@@H]3C4=C(CCN3C)C=CC=C42)C=C1)O

Technology Process of 11-Hydroxy-10-methylaporphine

There total 11 articles about 11-Hydroxy-10-methylaporphine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

(-)-(R)-11-methoxy-10-methylaporphine (142835-97-0) → (R)-11-hydroxy-10-methylaporphine (111635-19-9)

Guidance literature:

With hydrogen bromide; at 120 ℃; for 3h;

DOI:10.1039/c39920000845

Reference yield: 82.0%

(-)-3-deoxy-3-methylmorphine (142835-98-1) → (R)-11-hydroxy-10-methylaporphine (111635-19-9)

Guidance literature:

With methanesulfonic acid; at 95 ℃; for 1h;

DOI:10.1039/c39920000845

Reference yield:

(R)-11-Hydroxy-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline-10-carbaldehyde (111635-20-2) → (R)-11-hydroxy-10-methylaporphine (111635-19-9)

Guidance literature:

With hydrogenchloride; hydrogen; palladium on activated charcoal; In ethanol; at 50 ℃; for 26h; under 2327.2 Torr;

DOI:10.1021/jm00397a007

upstream raw materials:

(-)-3-deoxy-3-methylmorphine

(-)-(R)-11-methoxy-10-methylaporphine

(R)-11-Hydroxy-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline-10-carbaldehyde

(-)-(R)-11-methoxy-10-methylaporphine hydrochloride

Refernces

• 1、 Cannon, Joseph G.,Mohan, Prem,Bojarski, Jacek,Long, John Paul,Bhatnagar, Ranbir K.,et al.. "(R)-(-)-10-Methyl-11-hydroxyaporphine: A Highly Selective Serotonergic Agonist". . p. 313 - 318. Retrieved 1988.
• 2、 Hedberg, Martin H.,Johansson, Anette M.,Hacksell, Uli. "Facile Syntheses of Aporphine Derivatives". . p. 845 - 846. Retrieved 1992.