BOC-aminoether

Base Information

• Chemical Name: BOC-aminoether
• CAS No.: 86031-24-5
• Molecular Formula: C5H11NO3
• Molecular Weight: 133.147
• Hs Code.: 2922199090
• DSSTox Substance ID: DTXSID00475395
• Wikidata: Q82305904
• Mol file: 86031-24-5.mol

Synonyms:BOC-aminoether;Amino Tert-butyl Carbonate;86031-24-5;Hydroxylamine, O-[(1,1-dimethylethoxy)carbonyl]-;t-butyl aminocarbonate;SCHEMBL125547;DTXSID00475395;NLBBYLMMDFCTPI-UHFFFAOYSA-N;carbonic acid amino tert-butyl ester;HYDROXYLAMINE,O-[(1,1-DIMETHYLETHOXY)CARBONYL]-

Chemical Property of BOC-aminoether

Chemical Property:

• PSA: 61.55000
• LogP: 1.51210
• XLogP3: 0.8
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 3
• Exact Mass: 133.07389321
• Heavy Atom Count: 9
• Complexity: 105

Purity/Quality:

98% ^*data from raw suppliers

O-[(1,1-Dimethylethoxy)carbonyl]hydroxylamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C)(C)OC(=O)ON
• Uses: O-[(1,1-Dimethylethoxy)carbonyl]hydroxylamine is used as a reactant in the PEGylation and dimerization of expressed proteins.

Technology Process of BOC-aminoether

There total 4 articles about BOC-aminoether which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

di-tert-butyl dicarbonate (24424-99-5) → tert-Butyl N-hydroxycarbamate (36016-38-3) + O-(tert-butoxycarbonyl)hydroxylamine (86031-24-5)

Guidance literature:

With sodium hydroxide; hydroxylamine hydrochloride; In 1,4-dioxane; for 22h;

DOI:10.1016/S0040-4020(01)90416-8

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) → O-(tert-butoxycarbonyl)hydroxylamine (86031-24-5) + tert-butyl hydroxycarbamate

Guidance literature:

With sodium hydroxide; hydroxylamine hydrochloride; In 1,4-dioxane; at 0 - 25 ℃; for 2h; Yield given. Yields of byproduct given; pH = 10.3;

DOI:10.1016/S0040-4039(00)81372-6

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) → O-(tert-butoxycarbonyl)hydroxylamine (86031-24-5)

Guidance literature:

With hydroxylamine hydrochloride; sodium hydroxide; In 1,4-dioxane; at 20 ℃; for 2h; pH=10; Cooling with ice;

DOI:10.1002/anie.201812968

upstream raw materials:

di-tert-butyl dicarbonate

Downstream raw materials:

N-(tert-butoxycarbonyl)-1,4-phenylenediamine

tert–butyl (2–aminophenyl)carbamate

1-(tert-butyloxycarbamido)-2-[2,3-di(isopropylmercapto)benzamido]benzene

1-(tert-butyloxycarbamido)-4-[2,3-di(isopropylmercapto)benzamido]benzene