5,8-Dihydro-6-hydroxy-2-(2-nitrophenyl)-5,8-dioxo-7-quinolinecarbonitrile

Base Information

Chemical Name:5,8-Dihydro-6-hydroxy-2-(2-nitrophenyl)-5,8-dioxo-7-quinolinecarbonitrile
CAS No.:102072-86-6
Molecular Formula:C16H7 N3 O5
Molecular Weight:321.2439
Hs Code.:
DSSTox Substance ID:DTXSID50907075

Synonyms:102072-86-6;5,8-Dihydro-6-hydroxy-2-(2-nitrophenyl)-5,8-dioxo-7-quinolinecarbonitrile;DTXSID50907075;7-Quinolinecarbonitrile, 5,8-dihydro-6-hydroxy-2-(2-nitrophenyl)-5,8-dioxo-;8-Hydroxy-2-(2-nitrophenyl)-5,6-dioxo-5,6-dihydroquinoline-7-carbonitrile

Suppliers and Price of 5,8-Dihydro-6-hydroxy-2-(2-nitrophenyl)-5,8-dioxo-7-quinolinecarbonitrile

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 5,8-Dihydro-6-hydroxy-2-(2-nitrophenyl)-5,8-dioxo-7-quinolinecarbonitrile

Chemical Property:

Vapor Pressure:1.46E-13mmHg at 25°C
Boiling Point:564.1°Cat760mmHg
Flash Point:294.9°C
Density:1.64g/cm³
XLogP3:1.8
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:1
Exact Mass:321.03857033
Heavy Atom Count:24
Complexity:671

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC=C(C(=C1)C2=NC3=C(C=C2)C(=O)C(=O)C(=C3O)C#N)[N+](=O)[O-]

Technology Process of 5,8-Dihydro-6-hydroxy-2-(2-nitrophenyl)-5,8-dioxo-7-quinolinecarbonitrile

There total 6 articles about 5,8-Dihydro-6-hydroxy-2-(2-nitrophenyl)-5,8-dioxo-7-quinolinecarbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 102072-78-6
2-(o-nitrophenyl)-6,7-dicyano-5,8-quinolinedione

: 102072-86-6
2-(o-nitrophenyl)-6-hydroxy-7-cyano-5,8-quinolinedione

Guidance literature:: With sodium hydroxide;
DOI:10.1021/jm00158a002

Reference yield:

: 1466-88-2,66894-06-2
2-nitrocinnamic aldehyde

: 102072-86-6
2-(o-nitrophenyl)-6-hydroxy-7-cyano-5,8-quinolinedione

Guidance literature:: Multi-step reaction with 5 steps

1: 10 percent / sodium m-nitrobenzenesulfonate / acetic acid / 1.5 h / 100 - 115 °C

2: 75 percent / NaClO₃, concd HCl / 2 h / 25 °C

3: 86 percent / tetrahydrofuran; methanol; H₂O / 0.03 h / Heating

4: 65 percent / concd HNO₃ / acetic acid / 100 °C

5: 84 percent / 0.5 N NaOH

With hydrogenchloride; sodium chlorate; sodium hydroxide; nitric acid; sodium 3-nitrobenzenesulfonate; In tetrahydrofuran; methanol; water; acetic acid;
DOI:10.1021/jm00158a002

Reference yield:

: 61472-25-1
2-(o-nitrophenyl)-5,8-dimethoxyquinoline

: 102072-86-6
2-(o-nitrophenyl)-6-hydroxy-7-cyano-5,8-quinolinedione

Guidance literature:: Multi-step reaction with 4 steps

1: 75 percent / NaClO₃, concd HCl / 2 h / 25 °C

2: 86 percent / tetrahydrofuran; methanol; H₂O / 0.03 h / Heating

3: 65 percent / concd HNO₃ / acetic acid / 100 °C

4: 84 percent / 0.5 N NaOH

With hydrogenchloride; sodium chlorate; sodium hydroxide; nitric acid; In tetrahydrofuran; methanol; water; acetic acid;
DOI:10.1021/jm00158a002