(R)-2-(benzyloxycarbonylamino)-3-methoxypropanoic acid

Base Information

• Chemical Name: (R)-2-(benzyloxycarbonylamino)-3-methoxypropanoic acid
• CAS No.: 86096-35-7
• Molecular Formula: C12H15NO5
• Molecular Weight: 253.255
• Hs Code.: 2924299090
• European Community (EC) Number: 617-798-7
• DSSTox Substance ID: DTXSID20492665
• Wikidata: Q72516318
• Mol file: 86096-35-7.mol

Synonyms:86096-35-7;Cbz-O-methyl-D-Ser;(R)-2-(benzyloxycarbonylamino)-3-methoxypropanoic acid;(2R)-3-methoxy-2-(phenylmethoxycarbonylamino)propanoic acid;Cbz-O-Methyl-D-serine;(2R)-2-[(benzyloxycarbonyl)amino]-3-methoxy propanoic acid;SCHEMBL526571;DTXSID20492665;LQHGCFKPNOTYIQ-SNVBAGLBSA-N;CS-M1928;N-(benzyloxycarbonyl)-O-methyl-D-serine;HY-76992;N-[(Benzyloxy)carbonyl]-O-methyl-D-serine

Chemical Property of (R)-2-(benzyloxycarbonylamino)-3-methoxypropanoic acid

Chemical Property:

• PSA: 84.86000
• Density: 1.254
• LogP: 1.40330
• XLogP3: 0.9
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 7
• Exact Mass: 253.09502258
• Heavy Atom Count: 18
• Complexity: 276

Purity/Quality:

≥95% ^*data from raw suppliers

(R)-2-(Benzyloxycarbonylamino)-3-methoxypropanoicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COCC(C(=O)O)NC(=O)OCC1=CC=CC=C1
• Isomeric SMILES: COC[C@H](C(=O)O)NC(=O)OCC1=CC=CC=C1

Technology Process of (R)-2-(benzyloxycarbonylamino)-3-methoxypropanoic acid

There total 2 articles about (R)-2-(benzyloxycarbonylamino)-3-methoxypropanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(R)-2-Benzyloxycarbonylamino-3-methoxy-propionic acid methyl ester (209804-17-1) → (R)-2-N-(BENZYLOXYCARBONYL)AMINO-3-METHOXYPROPIONIC ACID (86096-35-7)

Guidance literature:

With sodium hydrogencarbonate; for 24h; Yield given; Ambient temperature;

DOI:10.1016/S0957-4166(98)00403-0

Reference yield:

→ (R)-2-N-(BENZYLOXYCARBONYL)AMINO-3-METHOXYPROPIONIC ACID (86096-35-7)

Guidance literature:

Reference yield: 78.0%

benzylamine (100-46-9) + (R)-2-N-(BENZYLOXYCARBONYL)AMINO-3-METHOXYPROPIONIC ACID (86096-35-7) + isobutyl chloroformate (543-27-1) → (R)-N-benzyl 2-N-(benzylcarboxycarbonyl)amino-3-methoxypropionamide (196601-68-0)

Guidance literature:

With 4-methyl-morpholine; In tetrahydrofuran;

upstream raw materials:

(R)-2-Benzyloxycarbonylamino-3-methoxy-propionic acid methyl ester

Downstream raw materials:

D-o-methylserine

(R)-N-benzyl 2-N-(benzylcarboxycarbonyl)amino-3-methoxypropionamide