differolide

Base Information

• Chemical Name: differolide
• CAS No.: 106750-00-9
• Molecular Formula: C₁₂H₁₂O₄
• Molecular Weight: 220.225
• Mol file: 106750-00-9.mol

Synonyms:1(3H)-Isobenzofuranone,4-(2,5-dihydro-2-oxo-3-furanyl)-3a,4,5,6-tetrahydro-, trans-(?à)-; (?à)-Differolide; 1(3H)-Isobenzofuranone,4-(2,5-dihydro-2-oxo-3-furanyl)-3a,4,5,6-tetrahydro-, trans-; Differolide

Chemical Property of differolide

Chemical Property:

• Vapor Pressure: 3.69E-11mmHg at 25°C
• Boiling Point: 526.1°Cat760mmHg
• Flash Point: 288.6°C
• PSA: 52.60000
• Density: 1.33g/cm³
• LogP: 0.97900

Purity/Quality:

98% ^*data from raw suppliers

Differolide ≥98%(HPLC) ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of differolide

There total 24 articles about differolide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

(5R,6R)-(+)-5-(2',5'-Dihydro-2'-oxo-3'-furanyl)-6-hydroxymethyl-1-cyclohexene-1-carboxylic Acid (151062-75-8) → (+)-Differolide (106750-00-9)

Guidance literature:

With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In 1,4-dioxane; for 12h; Ambient temperature;

Reference yield: 87.0%

(5S,6S)-(-)-5-(2',5'-Dihydro-2'-oxo-3'-furanyl)-6-hydroxymethyl-1-cyclohexene-1-carboxylic Acid (150989-91-6) → (-)-Differolide (106750-00-9)

Guidance literature:

With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In 1,4-dioxane; for 12h; Ambient temperature;

Reference yield:

3-vinyl-2(5H)-furanone (238433-82-4) → C12H12O4 + (+/-)-differolide (106750-00-9)

Guidance literature:

With 2,6-di-tert-butyl-4-methyl-phenol; In chloroform-d1; at 50 ℃; for 24h; Further Variations:; Reagents; Temperatures; Solvents; time; Product distribution;

DOI:10.1021/ol9905912

upstream raw materials:

(5S,6S)-(-)-5-(2',5'-Dihydro-2'-oxo-3'-furanyl)-6-hydroxymethyl-1-cyclohexene-1-carboxylic Acid

(-)-3-<(1'S,2'S)-2'-Hydroxymethyl-3'-formyl-3'-cyclohexenyl>-2(5H)-furanone

Methyl(1'R,2'S,3'S,4'R)-(-)-2',3'-Bis(benzyloxymethyl)-4'-hydroxycyclohexylacetate

Methyl (1'R,2'S)-(-)-2',3'-Bis(benzyloxymethyl)-3'-cyclohexenylacetate