2'-Deoxy-6-O-[2-(4-nitrophenyl)ethyl]guanosine

Base Information

• Chemical Name: 2'-Deoxy-6-O-[2-(4-nitrophenyl)ethyl]guanosine
• CAS No.: 86137-72-6
• Molecular Formula: C18H20N6O6
• Molecular Weight: 416.38800
• Mol file: 86137-72-6.mol

Synonyms:O-6-(p-nitrophenylethyl)-2''-deoxyguanosine;2''-deoxy-O6-[2-(4-nitrophenyl)ethyl]guanosine;2'-DEOXY-6-O-[2-(4-NITROPHENYL)ETHYL]GUANOSINE;6-O-(4-nitrophenylethyl)-2''-deoxyguanosine;6-O-(tert-Butyldiphenylsilyl)-3,4-O-isopropylidene-D-galactal;

Chemical Property of 2'-Deoxy-6-O-[2-(4-nitrophenyl)ethyl]guanosine

Chemical Property:

• PSA: 174.36000
• Density: 1.71
• LogP: 1.68330

Purity/Quality:

97% ^*data from raw suppliers

(2R,3S,5R)-5-(2-Amino-6-(4-nitrophenethoxy)-9H-purin-9-yl)-2-(hydroxymethyl)tetrahydrofuran-3-ol 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2'-Deoxy-6-O-[2-(4-nitrophenyl)ethyl]guanosine

There total 13 articles about 2'-Deoxy-6-O-[2-(4-nitrophenyl)ethyl]guanosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

2'-Deoxy-O6-<(p-nitrophenyl)ethyl>-N2,3',5'-triacetylguanosine (132183-38-1) → 2'-deoxy-O6-<2-(4-nitrophenyl)ethyl>guanosine (86137-72-6)

Guidance literature:

With ammonia; for 144h;

DOI:10.1016/S0040-4039(00)97168-5

Reference yield: 76.0%

N2,3',5'-triisobutyryl-O6-p-nitrophenylethyl-2'-deoxyguanosine (82921-55-9) → 2'-deoxy-O6-<2-(4-nitrophenyl)ethyl>guanosine (86137-72-6)

Guidance literature:

With ammonium hydroxide; In methanol; for 120h; Ambient temperature;

DOI:10.1016/0040-4020(84)85103-0

Reference yield:

2-amino-6-(2-(p-nitrophenyl)ethyloxy)-9-[2'-deoxy-β-D-erythropentofuranosyl]purine diacetate (108310-92-5) → 2'-deoxy-O6-<2-(4-nitrophenyl)ethyl>guanosine (86137-72-6)

Guidance literature:

With ammonia; In methanol; for 15h; Yield given; Ambient temperature;

DOI:10.1021/jm970434d

upstream raw materials:

2'-Deoxy-O⁶-<(p-nitrophenyl)ethyl>-N²,3',5'-triacetylguanosine

N²,3',5'-triisobutyryl-O⁶-p-nitrophenylethyl-2'-deoxyguanosine

2-amino-6-(2-(p-nitrophenyl)ethyloxy)-9-[2'-deoxy-β-D-erythropentofuranosyl]purine diacetate

2-(4-nitrophenyl)ethanol

Downstream raw materials:

2-fluoro-O⁶-(2-(p-nitrophenyl)ethyl)-2'-deoxyinosine

5'-O-(4,4'-Dimethoxytrityl)-6-O-[2-(4-nitrophenyl)ethyl]-2'-deoxy-2-fluoroinosine

5'-O-(4,4'-dimethoxytrityl)-6-O-(4-nitrophenylethyl)-2-N-(4,9,13-triazatridecane-1-yl)-2'-deoxyguanosine

5'-O-(4,4'-dimethoxytrityl)-6-O-(4-nitrophenylethyl)-2-N-[tris(N,N',N''-trifluoroacetyl)-4,9,13-triazatridecane-1-yl]-2'-deoxyguanosine