Benzeneacetic acid, a-[[[1-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)cyclopentyl]carbonyl]meth ylamino]-, methyl ester

Base Information

• Chemical Name: Benzeneacetic acid, a-[[[1-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)cyclopentyl]carbonyl]meth ylamino]-, methyl ester
• CAS No.: 862306-53-4
• Molecular Formula: C₂₄H₂₄N₂O₅
• Molecular Weight: 420.465
• Mol file: 862306-53-4.mol

Synonyms:

Chemical Property of Benzeneacetic acid, a-[[[1-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)cyclopentyl]carbonyl]meth ylamino]-, methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Benzeneacetic acid, a-[[[1-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)cyclopentyl]carbonyl]meth ylamino]-, methyl ester

There total 3 articles about Benzeneacetic acid, a-[[[1-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)cyclopentyl]carbonyl]meth ylamino]-, methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-(1,3-dioxoisoindolin-2-yl)cyclopentane-1-carboxylic acid (51971-46-1) + methyl 2-methylamino-2-phenylacetate hydrochloryde (27594-57-6) → {[1-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-cyclopentanecarbonyl]-methyl-amino}-phenyl-acetic acid methyl ester (862306-53-4)

Guidance literature:

1-(1,3-dioxoisoindolin-2-yl)cyclopentane-1-carboxylic acid; With oxalyl dichloride; In dichloromethane; at 20 ℃; for 2h;

methyl 2-methylamino-2-phenylacetate hydrochloryde; In dichloromethane; at 20 ℃; for 24h;

DOI:10.1016/j.tetlet.2005.05.074

Reference yield:

phthalic anhydride (85-44-9) → {[1-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-cyclopentanecarbonyl]-methyl-amino}-phenyl-acetic acid methyl ester (862306-53-4)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 0.5 h / 180 °C

2.1: (COCl)2 / CH₂Cl₂ / 2 h / 20 °C

2.2: DPEA / CH₂Cl₂ / 24 h / 20 °C

With oxalyl dichloride; In dichloromethane;

DOI:10.1016/j.tetlet.2005.05.074

Reference yield:

1-amino-1-cyclopentanecarboxylic acid (52-52-8) → {[1-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-cyclopentanecarbonyl]-methyl-amino}-phenyl-acetic acid methyl ester (862306-53-4)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 0.5 h / 180 °C

2.1: (COCl)2 / CH₂Cl₂ / 2 h / 20 °C

2.2: DPEA / CH₂Cl₂ / 24 h / 20 °C

With oxalyl dichloride; In dichloromethane;

DOI:10.1016/j.tetlet.2005.05.074

upstream raw materials:

1-(1,3-dioxoisoindolin-2-yl)cyclopentane-1-carboxylic acid

methyl 2-methylamino-2-phenylacetate hydrochloryde

phthalic anhydride

1-amino-1-cyclopentanecarboxylic acid

Refernces