N,N-Bis[2-(1,1-diMethylethoxy)-2-oxoethyl]-L-glutaMic Acid 1-(1,1-DiMethylethyl) Ester

Base Information

Chemical Name:N,N-Bis[2-(1,1-diMethylethoxy)-2-oxoethyl]-L-glutaMic Acid 1-(1,1-DiMethylethyl) Ester
CAS No.:862778-55-0
Molecular Formula:C₂₁H₃₇NO₈
Molecular Weight:431.527
Hs Code.:
Mol file:862778-55-0.mol

Synonyms:N,N-Bis[2-(1,1-dimethylethoxy)-2-oxoethyl]-L-glutamic Acid 1-(1,1-Dimethylethyl) Ester;

Suppliers and Price of N,N-Bis[2-(1,1-diMethylethoxy)-2-oxoethyl]-L-glutaMic Acid 1-(1,1-DiMethylethyl) Ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
N,N-Bis[2-(1,1-dimethylethoxy)-2-oxoethyl]-L-glutamicAcid1-(1,1-Dimethylethyl)Ester
25mg
$ 330.00

Medical Isotopes, Inc.
N,N-Bis[2-(1,1-dimethylethoxy)-2-oxoethyl]-L-glutamicAcid1-(1,1-Dimethylethyl)Ester
25 mg
$ 800.00

Total 2 raw suppliers

Chemical Property of N,N-Bis[2-(1,1-diMethylethoxy)-2-oxoethyl]-L-glutaMic Acid 1-(1,1-DiMethylethyl) Ester

Chemical Property:

PSA：119.44000
LogP:2.54690
Solubility.:Chloroform, DCM, DMSO, Ethyl Acetate

Purity/Quality:

99% ^*data from raw suppliers

N,N-Bis[2-(1,1-dimethylethoxy)-2-oxoethyl]-L-glutamicAcid1-(1,1-Dimethylethyl)Ester ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Uses N,N-Bis[2-(1,1-dimethylethoxy)-2-oxoethyl]-L-glutamic Acid 1-(1,1-Dimethylethyl) Ester is an intermediate in the synthesis of chelating agent for fluorescence labeling of histidine-tagged proteins to lipid membranes, which is a powerful mean for studying and monitoring protein interaction in cells.

Technology Process of N,N-Bis[2-(1,1-diMethylethoxy)-2-oxoethyl]-L-glutaMic Acid 1-(1,1-DiMethylethyl) Ester

There total 6 articles about N,N-Bis[2-(1,1-diMethylethoxy)-2-oxoethyl]-L-glutaMic Acid 1-(1,1-DiMethylethyl) Ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 862778-54-9
2-bis(tert-butoxycarbonylmethyl)aminopentanedioic acid 5-benzyl ester 1-tert-butyl ester

: 862778-55-0
2-(bis-tert-butoxycarbonylmethylamino)-pentanedioic acid 1-tert-butyl ester

Guidance literature:: With palladium on activated charcoal; hydrogen; In methanol; at 20 ℃; for 6h;
DOI:10.1016/j.bmcl.2017.05.087

Reference yield: 92.0%

: 862778-55-0
Glu-NTA

Guidance literature:

Reference yield:

: 5292-43-3
bromoacetic acid tert-butyl ester

: 862778-55-0
2-(bis-tert-butoxycarbonylmethylamino)-pentanedioic acid 1-tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 60 °C

2: palladium 10% on activated carbon; hydrogen / methanol / 2 h / 20 °C

With palladium 10% on activated carbon; hydrogen; N-ethyl-N,N-diisopropylamine; In methanol; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2014.04.096