3-(1H-indol-3-yl)-4-(3,4,5-trimethoxyphenyl)pyrrole-2,5-dione

Base Information

Chemical Name:3-(1H-indol-3-yl)-4-(3,4,5-trimethoxyphenyl)pyrrole-2,5-dione
CAS No.:863223-52-3
Molecular Formula:C21H18N2O5
Molecular Weight:378.384
Hs Code.:
ChEMBL ID:CHEMBL201511
DSSTox Substance ID:DTXSID40468140
Wikidata:Q82295246

Synonyms:CHEMBL201511;863223-52-3;3-(1H-indol-3-yl)-4-(3,4,5-trimethoxyphenyl)pyrrole-2,5-dione;SCHEMBL1155440;BDBM47167;DTXSID40468140;US8957103, Z1;3-(1H-Indol-3-yl)-4-(3,4,5-trimethoxyphenyl)-2,5-dihydro-1H-pyrrole-2,5-dione

Suppliers and Price of 3-(1H-indol-3-yl)-4-(3,4,5-trimethoxyphenyl)pyrrole-2,5-dione

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3-(1H-indol-3-yl)-4-(3,4,5-trimethoxyphenyl)pyrrole-2,5-dione

Chemical Property:

XLogP3:2.6
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:5
Exact Mass:378.12157168
Heavy Atom Count:28
Complexity:649

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC1=CC(=CC(=C1OC)OC)C2=C(C(=O)NC2=O)C3=CNC4=CC=CC=C43

Technology Process of 3-(1H-indol-3-yl)-4-(3,4,5-trimethoxyphenyl)pyrrole-2,5-dione

There total 6 articles about 3-(1H-indol-3-yl)-4-(3,4,5-trimethoxyphenyl)pyrrole-2,5-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 18372-22-0
2-(3-indolyl)oxoacetic acid methyl ester

: 91248-14-5
2-(3,4,5-trimethoxyphenyl)acetamide

: 863223-52-3
3-(1H-indol-3-yl)-4-(3,4,5-trimethoxyphenyl)-1H-pyrrole-2,5-dione

Guidance literature:: 2-(3-indolyl)oxoacetic acid methyl ester; 2-(3,4,5-trimethoxyphenyl)acetamide; With potassium tert-butylate; In tetrahydrofuran; at 0 - 20 ℃; Molecular sieve; Inert atmosphere;

With water; ammonium chloride; In tetrahydrofuran; at 20 ℃; Molecular sieve;
DOI:10.1016/j.bmc.2009.12.004

Reference yield: 72.0%

: 1038914-97-4
3-(3,4,5-trimethoxyphenyl)-4-(1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-indol-3-yl)-1H-pyrrole-2,5-dione

: 863223-52-3
3-(1H-indol-3-yl)-4-(3,4,5-trimethoxyphenyl)-1H-pyrrole-2,5-dione

Guidance literature:: With tetrabutyl ammonium fluoride; ethylenediamine; In tetrahydrofuran; N,N-dimethyl-formamide; for 2h; Reflux;
DOI:10.1021/jm8001185

Reference yield: 59.0%

: 51079-10-8
ethyl 2-(1H-indol-3-yl)-2-oxoacetate

: 91248-14-5
2-(3,4,5-trimethoxyphenyl)acetamide

: 863223-52-3
3-(1H-indol-3-yl)-4-(3,4,5-trimethoxyphenyl)-1H-pyrrole-2,5-dione

Guidance literature:: With potassium tert-butylate; In tetrahydrofuran; at 0 - 20 ℃; for 6h; Inert atmosphere;
DOI:10.3390/molecules21050570