Glycine, N-[(3,4-dihydro-5-methyl-2,4-dioxo-1(2H)-pyrimidinyl)acetyl]-N-[2-[[[(4,5 -dimethoxy-2-nitrophenyl)methoxy]carbonyl]amino]ethyl]-, 1,1-dimethylethyl ester

Base Information

Chemical Name:Glycine, N-[(3,4-dihydro-5-methyl-2,4-dioxo-1(2H)-pyrimidinyl)acetyl]-N-[2-[[[(4,5 -dimethoxy-2-nitrophenyl)methoxy]carbonyl]amino]ethyl]-, 1,1-dimethylethyl ester
CAS No.:864288-94-8
Molecular Formula:C25H33N5O11
Molecular Weight:579.564
Hs Code.:

Glycine,
N-[(3,4-dihydro-5-methyl-2,4-dioxo-1(2H)-pyrimidinyl)acetyl]-N-[2-[[[(4,5
-dimethoxy-2-nitrophenyl)methoxy]carbonyl]amino]ethyl]-,
1,1-dimethylethyl ester

Synonyms:

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Chemical Property of Glycine, N-[(3,4-dihydro-5-methyl-2,4-dioxo-1(2H)-pyrimidinyl)acetyl]-N-[2-[[[(4,5 -dimethoxy-2-nitrophenyl)methoxy]carbonyl]amino]ethyl]-, 1,1-dimethylethyl ester

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Technology Process of Glycine, N-[(3,4-dihydro-5-methyl-2,4-dioxo-1(2H)-pyrimidinyl)acetyl]-N-[2-[[[(4,5 -dimethoxy-2-nitrophenyl)methoxy]carbonyl]amino]ethyl]-, 1,1-dimethylethyl ester

There total 3 articles about Glycine, N-[(3,4-dihydro-5-methyl-2,4-dioxo-1(2H)-pyrimidinyl)acetyl]-N-[2-[[[(4,5 -dimethoxy-2-nitrophenyl)methoxy]carbonyl]amino]ethyl]-, 1,1-dimethylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 864288-93-7
[2-(4,5-dimethoxy-2-nitro-benzyloxycarbonylamino)-ethylamino]-acetic acid tert-butyl ester

: 20924-05-4
thymidyl acetic acid

: 864288-94-8
{[2-(4,5-dimethoxy-2-nitro-benzyloxycarbonylamino)-ethyl]-[(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-acetyl]-amino}-acetic acid tert-butyl ester

Guidance literature:: With propylphosphonic anhydride; N-ethyl-N,N-diisopropylamine; In ethyl acetate; N,N-dimethyl-formamide; at 20 ℃; for 2h;
DOI:10.1016/j.tet.2005.06.002

Reference yield:

: 42855-00-5
nitroveratryloxycarbonyl chloride

: 864288-94-8
{[2-(4,5-dimethoxy-2-nitro-benzyloxycarbonylamino)-ethyl]-[(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-acetyl]-amino}-acetic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 38 percent / ethyldiisopropylamine / CH₂Cl₂ / 0 - 20 °C

2: 98 percent / propylphosphonic anhydride; ethyldiisopropylamine / dimethylformamide; ethyl acetate / 2 h / 20 °C

With propylphosphonic anhydride; N-ethyl-N,N-diisopropylamine; In dichloromethane; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1016/j.tet.2005.06.002

Reference yield:

: 104732-23-2
(2-aminoethylamino)acetic acid tert-butyl ester

: 864288-94-8
{[2-(4,5-dimethoxy-2-nitro-benzyloxycarbonylamino)-ethyl]-[(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-acetyl]-amino}-acetic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 38 percent / ethyldiisopropylamine / CH₂Cl₂ / 0 - 20 °C

2: 98 percent / propylphosphonic anhydride; ethyldiisopropylamine / dimethylformamide; ethyl acetate / 2 h / 20 °C

With propylphosphonic anhydride; N-ethyl-N,N-diisopropylamine; In dichloromethane; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1016/j.tet.2005.06.002