Thiophene, 3-bromo-2-methyl-5-[3-(trifluoromethyl)phenyl]-

Base Information

• Chemical Name: Thiophene, 3-bromo-2-methyl-5-[3-(trifluoromethyl)phenyl]-
• CAS No.: 864362-75-4
• Molecular Formula: C12H8BrF3S
• Molecular Weight: 321.161
• Mol file: 864362-75-4.mol

Synonyms:3-bromo-2-methyl-5-(3-trifluoromethylphenyl)thiophene;Thiophene,3-bromo-2-methyl-5-[3-(trifluoromethyl)phenyl];

Chemical Property of Thiophene, 3-bromo-2-methyl-5-[3-(trifluoromethyl)phenyl]-

Chemical Property:

• PSA: 28.24000
• LogP: 5.50480

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Thiophene, 3-bromo-2-methyl-5-[3-(trifluoromethyl)phenyl]-

There total 1 articles about Thiophene, 3-bromo-2-methyl-5-[3-(trifluoromethyl)phenyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

3-bromo-1-trifluoromethylbenzene (401-78-5) + 3-bromo-2-methylthiophene-5-boronic acid (154566-69-5) → 3-bromo-2-methyl-5-(3-trifluoromethylphenyl)thiophene (864362-75-4)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In tetrahydrofuran; water; at 70 ℃; for 16h;

DOI:10.1016/j.saa.2007.10.026

Reference yield: 57.0%

3-bromo-2-methyl-5-(3-trifluoromethylphenyl)thiophene (864362-75-4) + 1-[2-methyl-5-phenyl-3-thienyl]heptafluorocyclopentene (308255-22-3) → 1-(2-methyl-5-phenyl-3-thienyl)-2-[2-methyl-5-(3-trifluoromethylphenyl)-3-thienyl]perfluorocyclopentene (1022930-42-2)

Guidance literature:

With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 2h; Inert atmosphere;

DOI:10.1016/j.saa.2007.10.026

Reference yield: 46.0%

octaperfluorocyclopentene (559-40-0) + 3-bromo-2-methyl-5-(3-trifluoromethylphenyl)thiophene (864362-75-4) → 1-[2-methyl-5-(2-trifluoromethylphenyl)-3-thienyl]perfluorocyclopentene

Guidance literature:

3-bromo-2-methyl-5-(3-trifluoromethylphenyl)thiophene; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 0.5h; Inert atmosphere;

octaperfluorocyclopentene; In tetrahydrofuran; hexane; at -78 ℃; for 2h; Inert atmosphere;

DOI:10.3184/174751917X14981229444839

upstream raw materials:

3-bromo-1-trifluoromethylbenzene

3-bromo-2-methylthiophene-5-boronic acid

Downstream raw materials:

1-(2-methyl-5-phenyl-3-thienyl)-2-[2-methyl-5-(3-trifluoromethylphenyl)-3-thienyl]perfluorocyclopentene

C₂₈H₁₇F₉S

1-(2-methylnaphthyl)-2-[2-methyl-5-(3-trifluoromethylphenyl)-3-thienyl]perfluorocyclopentene