5-(4-methylphenyl)-3H-furan-2-one

Base Information

• Chemical Name: 5-(4-methylphenyl)-3H-furan-2-one
• CAS No.: 21053-98-5
• Molecular Formula: C11H10 O2
• Molecular Weight: 174.199
• Hs Code.: 2932209090
• Mol file: 21053-98-5.mol

Synonyms:2(3H)-Furanone,5-p-tolyl- (8CI); 3-Butenoic acid, 4-hydroxy-4-p-tolyl-, g-lactone (6CI);5-(4-Methylphenyl)-2(3H)-furanone; NSC 69960

Chemical Property of 5-(4-methylphenyl)-3H-furan-2-one

Chemical Property:

• Vapor Pressure: 6.48E-06mmHg at 25°C
• Boiling Point: 378°Cat760mmHg
• Flash Point: 158.7°C
• PSA: 26.30000
• Density: 1.177g/cm³
• LogP: 2.28280

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-(4-methylphenyl)-3H-furan-2-one

There total 7 articles about 5-(4-methylphenyl)-3H-furan-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

3-(4-methylbenzoyl)propionic acid (4619-20-9) → 5-(4-methylphenyl)-3H-furan-2-one (21053-98-5)

Guidance literature:

With acetyl chloride; for 0.25h; Reflux;

DOI:10.1016/j.ejmech.2014.10.054

Reference yield: 78.0%

(furan-2-yloxy)-trimethylsilane (61550-02-5) + tris(para-tolyl)antimony diacetate (1005421-77-1,73694-89-0) → 5-(4-methylphenyl)-3H-furan-2-one (21053-98-5)

Guidance literature:

5percent PdCl₂; In 1,2-dimethoxyethane; acetonitrile; at 20 ℃;

DOI:10.1039/b006431i

Reference yield:

2-(4-methylphenyl)furan (17113-32-5) → 5-(4-methylphenyl)-3H-furan-2-one (21053-98-5)

Guidance literature:

Multi-step reaction with 2 steps

1: n-BuLi / hexane; diethyl ether / 3 h / 0 - 25 °C

2: 1.) chlorodimethoxyborane, 2.) MCPBA, Na₂CO₃ / 1.) ether, 0 deg C to room temp; 1 h, 2.) -78 to 0 deg C var. temp. and solv; and without Na₂CO₃

With n-butyllithium; chlorodimethoxyborane; sodium carbonate; 3-chloro-benzenecarboperoxoic acid; In diethyl ether; hexane;

DOI:10.1016/S0040-4039(00)95326-7

upstream raw materials:

3-(4-methylbenzoyl)propionic acid

(furan-2-yloxy)-trimethylsilane

tris(para-tolyl)antimony diacetate

2-(4-methylphenyl)furan

Downstream raw materials:

5-Hydroxy-1-methyl-5-(4-methylphenyl)pyrrolidin-2-one

γ-(p-Methylbenzoyl)-propionsaeureaethylamid

1-(4-methylphenyl)-4-phenyl-1,4-butanedione

1-methyl 2-(4-methylphenyl)succinate