Technology Process of Phosphinic amide,
N-[(2S)-2-amino-3-methyl-1,1-diphenylbutyl]-P,P-diphenyl-
There total 5 articles about Phosphinic amide,
N-[(2S)-2-amino-3-methyl-1,1-diphenylbutyl]-P,P-diphenyl- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
tert-butyl (Z)-N-{(2S)-1-[(diphenylphosphinoyl)imino]-3-methyl-1-phenyl-2-butyl}carbamate; phenylmagnesium bromide;
In
tetrahydrofuran; toluene;
at 25 ℃;
for 7h;
With
hydrogenchloride;
In
ethyl acetate;
at 20 ℃;
DOI:10.1021/jo049405i
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: triethylamine / tetrahydrofuran / -30 °C
2.1: toluene; tetrahydrofuran / 7 h / 25 °C
2.2: HCl / ethyl acetate / 20 °C
With
triethylamine;
In
tetrahydrofuran; toluene;
2.1: Grignard addition;
DOI:10.1021/jo049405i
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: tetrahydrofuran / 25 °C
2.1: hydroxylamine hydrochloride; sodium acetate / aq. ethanol / Heating
3.1: triethylamine / tetrahydrofuran / -30 °C
4.1: toluene; tetrahydrofuran / 7 h / 25 °C
4.2: HCl / ethyl acetate / 20 °C
With
hydroxylamine hydrochloride; sodium acetate; triethylamine;
In
tetrahydrofuran; ethanol; toluene;
4.1: Grignard addition;
DOI:10.1021/jo049405i
![tert-butyl (Z)-N-{(2S)-1-[(diphenylphosphinoyl)imino]-3-methyl-1-phenyl-2-butyl}carbamate](/Databaselist/images/loading.webp)
