Aphidicolan-16beta-ol

Base Information

Chemical Name:Aphidicolan-16beta-ol
CAS No.:101143-85-5
Molecular Formula:C₂₀H₃₄O
Molecular Weight:290.489
Hs Code.:
DSSTox Substance ID:DTXSID70332108
Wikidata:Q76100259
Metabolomics Workbench ID:28559

Synonyms:Aphidicolan-16beta-ol;101143-85-5;(1S,2S,7S,10S,12S,13R)-2,6,6,13-tetramethyltetracyclo[10.3.1.01,10.02,7]hexadecan-13-ol;CHEBI:29519;DTXSID70332108;LMPR0104160002;(4aS,6aS,8R,9R,11aS,11bS)-4,4,9,11b-tetramethyltetradecahydro-8,11a-methanocyclohepta[a]naphthalen-9-ol;(4aS,6aS,8S,9R,11aS,11bS)-4,4,9,11b-tetramethyltetradecahydro-8,11a-methanocyclohepta[a]naphthalen-9-ol

Suppliers and Price of Aphidicolan-16beta-ol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 0 raw suppliers

Chemical Property of Aphidicolan-16beta-ol

Chemical Property:

Vapor Pressure:2.76E-07mmHg at 25°C
Boiling Point:378.6°Cat760mmHg
Flash Point:161.7°C
Density:1.02g/cm³
XLogP3:5.8
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:1
Rotatable Bond Count:0
Exact Mass:290.260965704
Heavy Atom Count:21
Complexity:455

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1(CCCC2(C1CCC3C24CCC(C(C3)C4)(C)O)C)C
Isomeric SMILES:C[C@]12CCCC([C@@H]1CC[C@@H]3[C@@]24CC[C@@]([C@@H](C3)C4)(C)O)(C)C

Technology Process of Aphidicolan-16beta-ol

There total 44 articles about Aphidicolan-16beta-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 95998-93-9
C₁₉H₃₀O

: 41703-77-9,72690-42-7,96193-14-5,101143-85-5
(+/-)-2-desoxystemodinone

Guidance literature:: Multi-step reaction with 7 steps

1: 92 percent / SmI₂ / tetrahydrofuran / 22 h / Ambient temperature

2: 94 percent / Na, liq. NH₃ / tetrahydrofuran / 0.5 h / Heating

3: 1.) oxalyl chloride, DMSO, 2.) Et₃N / 1.) CH₂Cl₂, -60 deg C, 3 min, 2.) CH₂Cl₂, from -60 deg C to RT

4: Me₂AlCl / CH₂Cl₂; hexane / 0.02 h / -78 °C

5: 1.) oxalyl chloride, DMSO, 2.) Et₃N / 1.) CH₂Cl₂, -60 deg C, 3 min, 2.) CH₂Cl₂, from -60 deg C to RT

6: 87 percent / SmI₂, t-BuOH / tetrahydrofuran / 12 h / Ambient temperature

7: 1.) hydrazine monohydrate, KOH, 2.) m-chloroperbenzoic acid, 3.) LiEt₃BH

With potassium hydroxide; samarium diiodide; oxalyl dichloride; ammonia; sodium; dimethylaluminum chloride; lithium triethylborohydride; hydrazine hydrate; dimethyl sulfoxide; triethylamine; 3-chloro-benzenecarboperoxoic acid; tert-butyl alcohol; In tetrahydrofuran; hexane; dichloromethane;
DOI:10.1021/ja00101a012

Reference yield:

: (+/-)-(1'α,2'β,4'aα,8'aβ)-3',4',4'a,5',6',7',8',8'a-octahydro-4,5',5',8'a-tetramethylspiro<3-cyclohexene-1,1'(2'H)-naphthalene>-2'-methanol

: 41703-77-9,72690-42-7,96193-14-5,101143-85-5
(+/-)-2-desoxystemodinone

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) oxalyl chloride, DMSO, 2.) Et₃N / 1.) CH₂Cl₂, -60 deg C, 3 min, 2.) CH₂Cl₂, from -60 deg C to RT

2: Me₂AlCl / CH₂Cl₂; hexane / 0.02 h / -78 °C

3: 1.) oxalyl chloride, DMSO, 2.) Et₃N / 1.) CH₂Cl₂, -60 deg C, 3 min, 2.) CH₂Cl₂, from -60 deg C to RT

4: 87 percent / SmI₂, t-BuOH / tetrahydrofuran / 12 h / Ambient temperature

5: 1.) hydrazine monohydrate, KOH, 2.) m-chloroperbenzoic acid, 3.) LiEt₃BH

With potassium hydroxide; samarium diiodide; oxalyl dichloride; dimethylaluminum chloride; lithium triethylborohydride; hydrazine hydrate; dimethyl sulfoxide; triethylamine; 3-chloro-benzenecarboperoxoic acid; tert-butyl alcohol; In tetrahydrofuran; hexane; dichloromethane;
DOI:10.1021/ja00101a012

Reference yield:

: (+/-)-(1'α,2'β,4'aα,8'aβ)-3',4',4'a,5',6',7',8',8'a-octahydro-4,5',5',8'a-tetramethylspiro<3-cyclohexene-1,1'(2'H)-naphthalene>-2'-carboxaldehyde

: 41703-77-9,72690-42-7,96193-14-5,101143-85-5
(+/-)-2-desoxystemodinone

Guidance literature:: Multi-step reaction with 4 steps

1: Me₂AlCl / CH₂Cl₂; hexane / 0.02 h / -78 °C

2: 1.) oxalyl chloride, DMSO, 2.) Et₃N / 1.) CH₂Cl₂, -60 deg C, 3 min, 2.) CH₂Cl₂, from -60 deg C to RT

3: 87 percent / SmI₂, t-BuOH / tetrahydrofuran / 12 h / Ambient temperature

4: 1.) hydrazine monohydrate, KOH, 2.) m-chloroperbenzoic acid, 3.) LiEt₃BH

With potassium hydroxide; samarium diiodide; oxalyl dichloride; dimethylaluminum chloride; lithium triethylborohydride; hydrazine hydrate; dimethyl sulfoxide; triethylamine; 3-chloro-benzenecarboperoxoic acid; tert-butyl alcohol; In tetrahydrofuran; hexane; dichloromethane;
DOI:10.1021/ja00101a012