Technology Process of Belinostat
There total 25 articles about Belinostat which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
(2E)-3-{3-[(phenylamino)sulfonyl]phenyl}prop-2-enoic acid;
With
thionyl chloride; 1,8-diazabicyclo[5.4.0]undec-7-ene;
In
Isopropyl acetate;
at 20 - 30 ℃;
for 18.5h;
With
hydroxylamine;
In
tetrahydrofuran; Isopropyl acetate; water;
at 0 - 10 ℃;
With
hydrogenchloride;
In
tetrahydrofuran; Isopropyl acetate; water;
at 0 - 30 ℃;
for 1h;
- Guidance literature:
-
methyl (2E)-3-{3-[(phenylamino)sulfonyl]phenyl}prop-2-enoate;
With
hydroxylamine hydrochloride; potassium hydroxide;
In
ethanol;
at 0 ℃;
for 1h;
With
hydrogenchloride;
In
ethanol; water;
DOI:10.1080/00397910903277870
- Guidance literature:
-
With
hydroxylamine hydrochloride; sodium hydrogencarbonate;
In
tetrahydrofuran;
