4-Pyridazinecarboxylic acid, 5-(2-fluorobenzoyl)-

Base Information

• Chemical Name: 4-Pyridazinecarboxylic acid, 5-(2-fluorobenzoyl)-
• CAS No.: 86839-78-3
• Molecular Formula: C12H7FN2O3
• Molecular Weight: 246.198
• Mol file: 86839-78-3.mol

Synonyms:

Chemical Property of 4-Pyridazinecarboxylic acid, 5-(2-fluorobenzoyl)-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-Pyridazinecarboxylic acid, 5-(2-fluorobenzoyl)-

There total 4 articles about 4-Pyridazinecarboxylic acid, 5-(2-fluorobenzoyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

pyridazine-4-carboxylic acid (50681-25-9) + 2-Fluorobenzaldehyde (446-52-6) → 5-(2-Fluorobenzoyl)-4-pyridazinecarboxylic Acid (86839-78-3)

Guidance literature:

With tert.-butylhydroperoxide; iron(II) sulfate; In sulfuric acid; acetic acid; at 0 ℃; for 1h;

DOI:10.1002/ardp.19833160607

Reference yield:

ethyl pyridazine-4-carboxylate (39123-39-2) → 5-(2-Fluorobenzoyl)-4-pyridazinecarboxylic Acid (86839-78-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 46 percent / FeSO₄*7H₂O, t-BuOOH / aq. H₂SO₄; acetic acid / 5 °C

2: alkaline hydrolysis

With tert.-butylhydroperoxide; iron(II) sulfate; In sulfuric acid; acetic acid;

DOI:10.1002/ardp.19833160607

Reference yield:

2-Fluorobenzaldehyde (446-52-6) → 5-(2-Fluorobenzoyl)-4-pyridazinecarboxylic Acid (86839-78-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 46 percent / FeSO₄*7H₂O, t-BuOOH / aq. H₂SO₄; acetic acid / 5 °C

2: alkaline hydrolysis

With tert.-butylhydroperoxide; iron(II) sulfate; In sulfuric acid; acetic acid;

DOI:10.1002/ardp.19833160607

upstream raw materials:

pyridazine-4-carboxylic acid

2-Fluorobenzaldehyde

5-(2-Fluoro-benzoyl)-pyridazine-4-carboxylic acid ethyl ester

ethyl pyridazine-4-carboxylate

Downstream raw materials:

2-Acetyl-5-benzyl-2,4a-dihydropyridazino<4,5-b>quinolin-10(5H)-one

2-<(2,2-Dimethoxyethyl)amino>phenyl 4-Pyridazinyl Ketone

5-(2-Fluorbenzoyl)-4-pyridazincarbonsaeureazid

5-Benzylpyridazino<4,5-b>quinolin-10(5H)-one

Refernces