(2R)-1-Chloro-3-[[3-fluoro-4-(4-morpholinyl)phenyl]amino]-2-propanol

Base Information

Chemical Name:(2R)-1-Chloro-3-[[3-fluoro-4-(4-morpholinyl)phenyl]amino]-2-propanol
CAS No.:868405-66-7
Molecular Formula:C13H18ClFN2O2
Molecular Weight:288.75
Hs Code.:
UNII:SGY4BA844B

Synonyms:868405-66-7;(2R)-1-Chloro-3-[[3-fluoro-4-(4-morpholinyl)phenyl]amino]-2-propanol;Linezolid Impurity 8;SGY4BA844B;SCHEMBL2867969;NQGHQKBSPVNNDS-NSHDSACASA-N;N-(3-Chloro-2-(R)-hydroxypropyl)-3-fluoro-4-morpholinylaniline;n-[3-chloro-2-(r) -hydroxypropyl]-3-fluoro-4-morpholinyl aniline;N-[3-Chloro-2-(R)-hydroxypropyl]-3-fluoro-4-morpholinyl aniline;(R)-1-Chloro-3-[[3-fluoro-4-(morpholin-4-yl)phenyl]amino]propan-2-ol;1-Chloro-3-[[3-fluoro-4-(4-morpholinyl)phenyl]amino]-2-propanol, (2R)-;N-(3-Chloro-(2R)-2-hydroxypropyl)-3-fluoro-4-(4-morpholinyl)aniline;N-[3-chloro-2-(R)-hydroxypropyl]-3-fluoro-4-(4-morpholinyl)aniline;2-Propanol, 1-chloro-3-[[3-fluoro-4-(4-morpholinyl)phenyl]amino]-, (2R)-

Suppliers and Price of (2R)-1-Chloro-3-[[3-fluoro-4-(4-morpholinyl)phenyl]amino]-2-propanol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
(2R)-1-Chloro-3-[[3-fluoro-4-(4-morpholinyl)phenyl]amino]-2-propanol
5mg
$ 65.00

Total 9 raw suppliers

Chemical Property of (2R)-1-Chloro-3-[[3-fluoro-4-(4-morpholinyl)phenyl]amino]-2-propanol

Chemical Property:

Boiling Point:488.5±45.0 °C(Predicted)
PSA：44.73000
Density:1.320±0.06 g/cm3(Predicted)
LogP:1.81190
XLogP3:1.7
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:5
Exact Mass:288.1040837
Heavy Atom Count:19
Complexity:267

Purity/Quality:

99% ^*data from raw suppliers

(2R)-1-Chloro-3-[[3-fluoro-4-(4-morpholinyl)phenyl]amino]-2-propanol ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1COCCN1C2=C(C=C(C=C2)NCC(CCl)O)F
Isomeric SMILES:C1COCCN1C2=C(C=C(C=C2)NC[C@H](CCl)O)F
Uses (2R)-1-Chloro-3-[[3-fluoro-4-(4-morpholinyl)phenyl]amino]-2-propanol is an intermediate in synthesizing N-[(2S)-3-Amino-2-hydroxypropyl]-N-[3-fluoro-4-(4-morpholinyl)phenyl] Acetamide Hydrochloride (A609075), one of the major thermal degradation products of Linezolid (L466500). Linezolid impurity.

Technology Process of (2R)-1-Chloro-3-[[3-fluoro-4-(4-morpholinyl)phenyl]amino]-2-propanol

There total 3 articles about (2R)-1-Chloro-3-[[3-fluoro-4-(4-morpholinyl)phenyl]amino]-2-propanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 51594-55-9,24969-06-0,13403-37-7
(R)-(-)-epichlorohydrin

: 93246-53-8
3-fluoro-4-(morpholinyl)aniline

: 868405-66-7
N-[3-chloro-2-(R)-hydroxypropyl]-3-fluoro-4-(morpholin-4-yl)aniline

Guidance literature:: In isopropyl alcohol; for 16h; Heating / reflux;

Reference yield:

: 369-34-6
3,4-difluoronitrobenzene

: 868405-66-7
N-[3-chloro-2-(R)-hydroxypropyl]-3-fluoro-4-(morpholin-4-yl)aniline

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine / acetonitrile / 6 h / 40 - 50 °C / Reflux

2: hydrogen / Raney nickel / methanol / 8 h / 45 - 50 °C / 2942.29 Torr / Autoclave

3: tert-butyl alcohol / 16 h / Reflux

With hydrogen; triethylamine; Raney nickel; In methanol; acetonitrile; tert-butyl alcohol;

Reference yield:

: 2689-39-6
3-fluoro-4-(4-morpholinyl)nitrobenzene

: 868405-66-7
N-[3-chloro-2-(R)-hydroxypropyl]-3-fluoro-4-(morpholin-4-yl)aniline

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogen / Raney nickel / methanol / 8 h / 45 - 50 °C / 2942.29 Torr / Autoclave

2: tert-butyl alcohol / 16 h / Reflux

With hydrogen; Raney nickel; In methanol; tert-butyl alcohol;