Technology Process of 1H-Imidazole-1-carboxylic acid, 4-(4-hydroxycyclohexyl)-,
1,1-dimethylethyl ester
There total 9 articles about 1H-Imidazole-1-carboxylic acid, 4-(4-hydroxycyclohexyl)-,
1,1-dimethylethyl ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 9 steps
1.1: 98 percent / H2 / Rh/C / tetrahydrofuran / 18 h / 76000 Torr
2.1: 90 percent / pyridinium chlorochromate; Celite; sodium carbonate / CH2Cl2 / 4 h / 20 °C
3.1: 90 percent / p-toluenesulfonic acid monohydrate / toluene / 18 h / Heating
4.1: 95 percent / LiAlH4 / diethyl ether / 3 h / 20 °C
5.1: 97 percent / oxalyl chloride; DMSO; triethylamine / CH2Cl2 / 2 h / -60 - 20 °C
6.1: sodium cyanide / ethanol / 2 h
6.2: 75 percent / NH3 / ethanol / 16 h / 90 - 110 °C
7.1: 94 percent / HCl / 1 h / 20 °C
8.1: 70 percent / triethylamine / CHCl3 / 16 h / 20 °C
9.1: 65 percent / sodium borohydride / methanol / 16 h / 20 °C
With
hydrogenchloride; sodium cyanide; sodium tetrahydroborate; lithium aluminium tetrahydride; oxalyl dichloride; Celite; hydrogen; sodium carbonate; toluene-4-sulfonic acid; dimethyl sulfoxide; triethylamine; pyridinium chlorochromate;
Rh on carbon;
In
tetrahydrofuran; methanol; diethyl ether; ethanol; dichloromethane; chloroform; toluene;
5.1: Swern oxidation;
DOI:10.1016/j.bmc.2005.09.002
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 70 percent / triethylamine / CHCl3 / 16 h / 20 °C
2: 65 percent / sodium borohydride / methanol / 16 h / 20 °C
With
sodium tetrahydroborate; triethylamine;
In
methanol; chloroform;
DOI:10.1016/j.bmc.2005.09.002