L-Leucinamide, N-[(1,1-dimethylethoxy)carbonyl]-L-alanyl-L-tyrosyl-N-[3-chloro-1-(1-meth ylethyl)-2-oxopropyl]-, (S)-

Base Information

Chemical Name:L-Leucinamide, N-[(1,1-dimethylethoxy)carbonyl]-L-alanyl-L-tyrosyl-N-[3-chloro-1-(1-meth ylethyl)-2-oxopropyl]-, (S)-
CAS No.:86961-34-4
Molecular Formula:C₂₉H₄₅ClN₄O₇
Molecular Weight:597.152
Hs Code.:

Synonyms:

Suppliers and Price of L-Leucinamide, N-[(1,1-dimethylethoxy)carbonyl]-L-alanyl-L-tyrosyl-N-[3-chloro-1-(1-meth ylethyl)-2-oxopropyl]-, (S)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of L-Leucinamide, N-[(1,1-dimethylethoxy)carbonyl]-L-alanyl-L-tyrosyl-N-[3-chloro-1-(1-meth ylethyl)-2-oxopropyl]-, (S)-

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of L-Leucinamide, N-[(1,1-dimethylethoxy)carbonyl]-L-alanyl-L-tyrosyl-N-[3-chloro-1-(1-meth ylethyl)-2-oxopropyl]-, (S)-

There total 7 articles about L-Leucinamide, N-[(1,1-dimethylethoxy)carbonyl]-L-alanyl-L-tyrosyl-N-[3-chloro-1-(1-meth ylethyl)-2-oxopropyl]-, (S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 17.0%

: 107831-79-8
Val-CMK hydrochloride

: 86961-40-2
Boc-Ala-Tyr-Leu-OH

: 86961-34-4
Boc-Ala-Tyr-Leu-Val-CH₂Cl

Guidance literature:: With benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; In N,N-dimethyl-formamide; 1.) -15 deg C, 1 h, 2.) 4 deg C, 18 h;
DOI:10.1248/cpb.35.3576

Reference yield:

: 61-90-5,21675-61-6,25248-98-0,70-45-1
L-leucine

: 86961-34-4
Boc-Ala-Tyr-Leu-Val-CH₂Cl

Guidance literature:: Multi-step reaction with 2 steps

1: 39 percent / triethylamine / dimethylformamide; H₂O / 1.) -40 deg C, 30 min, 2.) 4 deg C, 48 h

2: 17 percent / 1-hydroxybenzotriazole, triethylamine, N,N'-dicyclohexylcarbodiimide / dimethylformamide / 1.) -15 deg C, 1 h, 2.) 4 deg C, 18 h

With benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; In water; N,N-dimethyl-formamide;
DOI:10.1248/cpb.35.3576

Reference yield:

: 15761-38-3
L-N-Boc-Ala

: 86961-34-4
Boc-Ala-Tyr-Leu-Val-CH₂Cl

Guidance literature:: Multi-step reaction with 5 steps

1: 1-hydroxybenzotriazole, triethylamine, N,N'-dicyclohexylcarbodiimide / dimethylformamide / 1.) -15 deg C, 1 h, 2.) room temp., 18 h

2: 4.4 g / 80percent hydrazine hydrate / methanol / 15 h / Ambient temperature

3: 8.4 N HCl, isoamyl nitrite / dioxane / -40 °C

4: 39 percent / triethylamine / dimethylformamide; H₂O / 1.) -40 deg C, 30 min, 2.) 4 deg C, 48 h

5: 17 percent / 1-hydroxybenzotriazole, triethylamine, N,N'-dicyclohexylcarbodiimide / dimethylformamide / 1.) -15 deg C, 1 h, 2.) 4 deg C, 18 h

With hydrogenchloride; benzotriazol-1-ol; hydrazine hydrate; triethylamine; dicyclohexyl-carbodiimide; isopentyl nitrite; In 1,4-dioxane; methanol; water; N,N-dimethyl-formamide;
DOI:10.1248/cpb.35.3576