Glycine, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-D-phenylalanyl-N-[[4-[[[(phenylmeth oxy)carbonyl]amino]methyl]phenyl]methyl]-

Base Information

Chemical Name:Glycine, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-D-phenylalanyl-N-[[4-[[[(phenylmeth oxy)carbonyl]amino]methyl]phenyl]methyl]-
CAS No.:869782-23-0
Molecular Formula:C42H39N3O7
Molecular Weight:697.788
Hs Code.:

Synonyms:

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Chemical Property of Glycine, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-D-phenylalanyl-N-[[4-[[[(phenylmeth oxy)carbonyl]amino]methyl]phenyl]methyl]-

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of Glycine, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-D-phenylalanyl-N-[[4-[[[(phenylmeth oxy)carbonyl]amino]methyl]phenyl]methyl]-

There total 5 articles about Glycine, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-D-phenylalanyl-N-[[4-[[[(phenylmeth oxy)carbonyl]amino]methyl]phenyl]methyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₃₄H₃₃N₃O₅

: 501-53-1,94274-21-2
benzyl chloroformate

: 869782-23-0
Fmoc-(D)-Phe-N(4-Cbz-NH-CH₂-benzyl)-Gly

Guidance literature:: C₃₄H₃₃N₃O₅; benzyl chloroformate; With sodium carbonate; In 1,4-dioxane; at 0 - 20 ℃; for 1h;

With hydrogenchloride; water; pH=1;

Reference yield:

: 108468-00-4
tert-butyl 4-(aminomethyl)benzylcarbamate

: 869782-23-0
Fmoc-(D)-Phe-N(4-Cbz-NH-CH₂-benzyl)-Gly

Guidance literature:: Multi-step reaction with 5 steps

1.1: triethylamine / tetrahydrofuran

2.1: 2,4,6-trimethyl-pyridine; trichloromethyl chloroformate / dichloromethane / 0.25 h

2.2: 3.17 h

3.1: ammonium formate; acetic acid / palladium 10% on activated carbon / methanol / 0.5 h / 0 °C

4.1: trifluoroacetic acid

5.1: sodium carbonate / 1,4-dioxane / 1 h / 0 - 20 °C

5.2: pH 1

With 2,4,6-trimethyl-pyridine; ammonium formate; sodium carbonate; acetic acid; triethylamine; trifluoroacetic acid; trichloromethyl chloroformate; palladium 10% on activated carbon; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane;

Reference yield:

: 869749-58-6
N-(4-Boc-NH-CH₂-benzyl)-glycine benzylester

: 869782-23-0
Fmoc-(D)-Phe-N(4-Cbz-NH-CH₂-benzyl)-Gly

Guidance literature:: Multi-step reaction with 4 steps

1.1: 2,4,6-trimethyl-pyridine; trichloromethyl chloroformate / dichloromethane / 0.25 h

1.2: 3.17 h

2.1: ammonium formate; acetic acid / palladium 10% on activated carbon / methanol / 0.5 h / 0 °C

3.1: trifluoroacetic acid

4.1: sodium carbonate / 1,4-dioxane / 1 h / 0 - 20 °C

4.2: pH 1

With 2,4,6-trimethyl-pyridine; ammonium formate; sodium carbonate; acetic acid; trifluoroacetic acid; trichloromethyl chloroformate; palladium 10% on activated carbon; In 1,4-dioxane; methanol; dichloromethane;