(1-Benzylpiperidin-4-yl)methanamine

Base Information

• Chemical Name: (1-Benzylpiperidin-4-yl)methanamine
• CAS No.: 88915-26-8
• Molecular Formula: C13H20 N2
• Molecular Weight: 204.315
• Hs Code.: 2933399090
• European Community (EC) Number: 837-894-4
• DSSTox Substance ID: DTXSID70363891
• Wikidata: Q72442824
• Mol file: 88915-26-8.mol

Synonyms:88915-26-8;(1-benzylpiperidin-4-yl)methanamine;(1-Benzyl-4-Piperidinyl)Methylamine;4-aminomethyl-1-benzylpiperidine;(1-benzylpiperidin-4-yl)methylamine;[(1-benzylpiperidin-4-yl)methyl]amine;1-(1-benzylpiperidin-4-yl)methanamine;4-piperidinemethanamine, 1-(phenylmethyl)-;C-(1-Benzylpiperidin-4-yl)methylamine;c-(1-benzyl-piperidin-4-yl)-methylamine;SCHEMBL1061878;1-benzyl-4-aminomethylpiperidine;1-benzyl-piperidin-4-methylamine;4-Aminomethyl-1-benzyl piperdine;DTXSID70363891;4-aminomethyl-1-benzyl-piperidine;(1-benzyl-4-piperidyl)methylamine;4-(aminomethyl)-1-benzylpiperidine;AMY19384;BBL038077;MFCD04116211;STK347048;AKOS000210617;1-(1-Benzyl-4-piperidinyl)methanamine;DS-1519;FS-2025;SB44044;1-(phenylmethyl)4-piperidinemethanamine;4-aminomethyl-1-phenylmethyl piperidine;1-(phenylmethyl)-4-piperidinemethanamine;([(1-Benzylpiperidin-4-yl)methyl]amine);BB 0220167;CS-0122586;FT-0656779;EN300-54071;A843001;J-504321;Z326203048

Chemical Property of (1-Benzylpiperidin-4-yl)methanamine

Chemical Property:

• Vapor Pressure: 0.00095mmHg at 25°C
• Boiling Point: 125 °C
• PKA: 10.13±0.29(Predicted)
• Flash Point: 126.4°C
• PSA: 29.26000
• Density: 1.018±0.06 g/cm3(Predicted)
• LogP: 2.49550
• XLogP3: 1.6
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 204.162648646
• Heavy Atom Count: 15
• Complexity: 167

Purity/Quality:

97% ^*data from raw suppliers

(1-Benzylpiperidin-4-yl)methanamine ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi,C
• Statements: 34-36/37/38-21/22
• Safety Statements: 26-36/37/39-45-23

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CN(CCC1CN)CC2=CC=CC=C2

Technology Process of (1-Benzylpiperidin-4-yl)methanamine

There total 26 articles about (1-Benzylpiperidin-4-yl)methanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

1-benzyl-piperidine-4-carboxylic acid amide (62992-68-1) → 4-aminomethyl-1-benzylpiperidine (88915-26-8)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 45 ℃; for 4h;

DOI:10.1016/S0223-5234(99)80083-X DOI:10.1016/S0223-5234(99)00158-0

Reference yield: 82.3%

1-benzylpiperidine-4-carbonitrile (62718-31-4) → 4-aminomethyl-1-benzylpiperidine (88915-26-8)

Guidance literature:

1-benzylpiperidine-4-carbonitrile; With lithium aluminium tetrahydride; In diethyl ether; at 0 - 20 ℃; for 24h;

With sodium hydroxide; water; In diethyl ether;

Reference yield: 73.6%

1-benzoylpiperidine-4-carboxamide (375355-32-1) → 4-aminomethyl-1-benzylpiperidine (88915-26-8)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; Heating;

DOI:10.1016/j.bmcl.2004.07.005

upstream raw materials:

1-benzyl-piperidine-4-carboxylic acid amide

N-((1-benzylpiperidin-4-yl)methyl)-1-phenylmethanimine

1-benzoylpiperidine-4-carboxamide

4-carbethoxypiperidine

Downstream raw materials:

tert-butyl ((1-benzylpiperidin-4-yl)methyl)carbamate