3-Quinolinecarbonitrile, 4-[(3-hydroxy-4-methylphenyl)amino]-6-methoxy-7-(2-methoxyethoxy)-

Base Information

Chemical Name:3-Quinolinecarbonitrile, 4-[(3-hydroxy-4-methylphenyl)amino]-6-methoxy-7-(2-methoxyethoxy)-
CAS No.:870959-69-6
Molecular Formula:C21H21N3O4
Molecular Weight:379.415
Hs Code.:

Synonyms:

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Chemical Property of 3-Quinolinecarbonitrile, 4-[(3-hydroxy-4-methylphenyl)amino]-6-methoxy-7-(2-methoxyethoxy)-

Chemical Property:

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Technology Process of 3-Quinolinecarbonitrile, 4-[(3-hydroxy-4-methylphenyl)amino]-6-methoxy-7-(2-methoxyethoxy)-

There total 6 articles about 3-Quinolinecarbonitrile, 4-[(3-hydroxy-4-methylphenyl)amino]-6-methoxy-7-(2-methoxyethoxy)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₁H₂₁N₃O₄*ClH

: 870959-69-6
4-[(3-hydroxy-4-methylphenyl)amino]-6-methoxy-7-(2-methoxyethoxy)quinoline-3-carbonitrile

Guidance literature:: With water; sodium hydrogencarbonate; In dichloromethane;

Reference yield:

: 870959-66-3
3-methoxy-4-(2-methoxyethoxy)benzoic acid methyl ester

: 870959-69-6
4-[(3-hydroxy-4-methylphenyl)amino]-6-methoxy-7-(2-methoxyethoxy)quinoline-3-carbonitrile

Guidance literature:: Multi-step reaction with 6 steps

1: nitric acid / acetic acid / 2.25 h / 50 °C

2: water; iron; ammonium chloride / ethanol / 0.5 h / Heating / reflux

3: 100 °C

4: n-butyllithium; acetic acid; acetonitrile / tetrahydrofuran; hexane / 1.5 h / -78 - 20 °C

5: pyridine hydrochloride / isopropyl alcohol / 1 h / Heating / reflux

6: water; sodium hydrogencarbonate / dichloromethane

With n-butyllithium; water; nitric acid; pyridine hydrochloride; iron; sodium hydrogencarbonate; ammonium chloride; acetic acid; acetonitrile; In tetrahydrofuran; ethanol; hexane; dichloromethane; acetic acid; isopropyl alcohol;

Reference yield:

: 3943-74-6
4-hydroxy-3-methoxybenzoic acid methyl ester

: 870959-69-6
4-[(3-hydroxy-4-methylphenyl)amino]-6-methoxy-7-(2-methoxyethoxy)quinoline-3-carbonitrile

Guidance literature:: Multi-step reaction with 7 steps

1: potassium carbonate / acetone / 23 h / Heating / reflux

2: nitric acid / acetic acid / 2.25 h / 50 °C

3: water; iron; ammonium chloride / ethanol / 0.5 h / Heating / reflux

4: 100 °C

5: n-butyllithium; acetic acid; acetonitrile / tetrahydrofuran; hexane / 1.5 h / -78 - 20 °C

6: pyridine hydrochloride / isopropyl alcohol / 1 h / Heating / reflux

7: water; sodium hydrogencarbonate / dichloromethane

With n-butyllithium; water; nitric acid; pyridine hydrochloride; iron; sodium hydrogencarbonate; potassium carbonate; ammonium chloride; acetic acid; acetonitrile; In tetrahydrofuran; ethanol; hexane; dichloromethane; acetic acid; isopropyl alcohol; acetone;