6-Iodo-4'-methylaminoflavone

Base Information

Chemical Name:6-Iodo-4'-methylaminoflavone
CAS No.:871101-30-3
Molecular Formula:C₁₆H₁₂INO₂
Molecular Weight:377.181
Hs Code.:2932999099
ChEMBL ID:CHEMBL224643
DSSTox Substance ID:DTXSID20469771
Pharos Ligand ID:RQ7VGV41JG29
Wikidata:Q82297628
Mol file:871101-30-3.mol

Synonyms:6-iodo-4'-methylaminoflavone;871101-30-3;CHEMBL224643;6-iodo-2-(4-methylaminophenyl)-chromen-4-one;6-IODO-2-(4-METHYLAMINOPHENYL)-4-CHROMENONE;6-iodo-4''-methylaminoflavone;SCHEMBL4991516;DTXSID20469771;QIZWRTNISFPGTO-UHFFFAOYSA-N;BDBM50176896;PD182950;6-iodo-2-(4-(methylamino)phenyl)-4H-chromen-4-one

Suppliers and Price of 6-Iodo-4'-methylaminoflavone

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
6-IODO-2-(4-METHYLAMINOPHENYL)-4-CHROMENONE 95.00%
5G
$ 1206.98

Total 1 raw suppliers

Chemical Property of 6-Iodo-4'-methylaminoflavone

Chemical Property:

PSA：42.24000
LogP:4.17930
XLogP3:4.2
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:2
Exact Mass:376.99128
Heavy Atom Count:20
Complexity:401

Purity/Quality:: 6-IODO-2-(4-METHYLAMINOPHENYL)-4-CHROMENONE 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CNC1=CC=C(C=C1)C2=CC(=O)C3=C(O2)C=CC(=C3)I

Technology Process of 6-Iodo-4'-methylaminoflavone

There total 9 articles about 6-Iodo-4'-methylaminoflavone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 28.7%

: 871101-28-9
6-(tributylstannyl)-4'-methylaminoflavone

: 871101-30-3
6-iodo-4'-methylaminoflavone

Guidance literature:: 6-(tributylstannyl)-4'-methylaminoflavone; With iodine; In chloroform; at 20 ℃; for 0.166667h;

With sodium hydrogensulfite; In chloroform; water;

Reference yield:

: 871101-26-7
6-bromo-4'-methylaminoflavone

: 871101-30-3
6-iodo-4'-methylaminoflavone

Guidance literature:: 6-bromo-4'-methylaminoflavone; With tetrakis(triphenylphosphine) palladium⁽⁰⁾; bis(tri-n-butyltin); triethylamine; In 1,4-dioxane; at 90 ℃; for 6h;

With iodine; In chloroform; at 20 ℃; for 0.166667h;
DOI:10.1021/jm050635e

Reference yield:

: 6-bromo-2-(4-methyleneamino-phenyl)-chromen-4-one

: 871101-30-3
6-iodo-4'-methylaminoflavone

Guidance literature:: Multi-step reaction with 2 steps

1.1: 121 mg / NaBH₄ / methanol / 2 h / Heating

2.1: bis(tributyltin); (Ph₃P)4Pd; Et₃N / dioxane / 6 h / 90 °C

2.2: 20 mg / I₂ / CHCl₃ / 0.17 h / 20 °C

With sodium tetrahydroborate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; bis(tri-n-butyltin); triethylamine; In 1,4-dioxane; methanol;
DOI:10.1021/jm050635e