Cyclohexanone, 2,6-bis(4-pyridinylmethylene)-, (2E,6E)-

Base Information

Chemical Name:Cyclohexanone, 2,6-bis(4-pyridinylmethylene)-, (2E,6E)-
CAS No.:871361-88-5
Molecular Formula:C₁₈H₁₆N₂O
Molecular Weight:276.338
Hs Code.:
DSSTox Substance ID:DTXSID00399769
Mol file:871361-88-5.mol

Synonyms:2,6-bis(pyridin-4-ylmethylidene)cyclohexan-1-one;Cyclohexanone, 2,6-bis(4-pyridinylmethylene)-, (2E,6E)-;(2E,6E)-2,6-bis(pyridin-4-ylmethylidene)cyclohexan-1-one;DTXSID00399769;FT-0700497;2,6-bis(pyridin-4-ylmethylene)-cyclohexanone

Suppliers and Price of Cyclohexanone, 2,6-bis(4-pyridinylmethylene)-, (2E,6E)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
SC66
10mg
$ 297.00

Usbiological
SC 66
10mg
$ 339.00

TRC
SC66
10mg
$ 100.00

Tocris
SC66 ≥98%(HPLC)
10
$ 90.00

Tocris
SC66 ≥98%(HPLC)
50
$ 378.00

Sigma-Aldrich
SC66 ≥98% (HPLC)
25mg
$ 423.00

Sigma-Aldrich
SC66 ≥98% (HPLC)
5 mg
$ 111.00

DC Chemicals
SC-66 >98%
1 g
$ 1000.00

CSNpharm
SC66
10mg
$ 60.00

CSNpharm
SC66
100mg
$ 320.00

Total 14 raw suppliers

Chemical Property of Cyclohexanone, 2,6-bis(4-pyridinylmethylene)-, (2E,6E)-

Chemical Property:

PSA：42.85000
LogP:3.69660
Storage Temp.:2-8°C
Solubility.:DMSO: ≥5mg/mL (warmed)
XLogP3:2.9
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:2
Exact Mass:276.126263138
Heavy Atom Count:21
Complexity:389

Purity/Quality:

99%, ^*data from raw suppliers

SC66 ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CC(=CC2=CC=NC=C2)C(=O)C(=CC3=CC=NC=C3)C1
Description Akt activation requires binding of its pleckstrin homology domain (PHD) to membrane-associated phosphatidylinositol-3,4,5-trisphosphate (PIP3) or phosphatidylinositol-3,4-bisphosphate (PIP2). Increased Akt activity, e.g., through a gain-of-function mutation in the PHD of Akt1, is pivotal to many types of cancer. Activated Akt may be regulated by various events, including ubiquitination-mediated deactivation. SC-66 is an allosteric inhibitor of Akt that facilitates both ubiquitination and deactivation of Akt. At 4 μg/ml, SC-66 inhibits Akt activity in HEK293T cells and in HEK293 cells stably expressing Akt with the gain-of-function pleckstrin homology domain mutation, promoting cell death. In nude mice inoculated with HEK293T cells, SC-66 (15 mg/kg) suppresses tumor growth.
Uses SC 66 is an analog of curcumin that can inhibit the activity of ATP-binding cassette transporters in cancer multidrug resistance.

Technology Process of Cyclohexanone, 2,6-bis(4-pyridinylmethylene)-, (2E,6E)-

There total 6 articles about Cyclohexanone, 2,6-bis(4-pyridinylmethylene)-, (2E,6E)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%