methyl 3-(biphenyl-4-yl)butanoate

Base Information

• Chemical Name: methyl 3-(biphenyl-4-yl)butanoate
• CAS No.: 24254-67-9
• Molecular Formula: C₁₇H₁₈O₂
• Molecular Weight: 254.329
• Mol file: 24254-67-9.mol

Synonyms:4-Biphenylpropionicacid, b-methyl-, methyl ester (8CI)

Chemical Property of methyl 3-(biphenyl-4-yl)butanoate

Chemical Property:

• Vapor Pressure: 1.8E-05mmHg at 25°C
• Boiling Point: 363.5°Cat760mmHg
• Flash Point: 138.1°C
• PSA: 26.30000
• Density: 1.054g/cm³
• LogP: 4.02020

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of methyl 3-(biphenyl-4-yl)butanoate

There total 3 articles about methyl 3-(biphenyl-4-yl)butanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

diazomethane (186581-53-3,908094-01-9,334-88-3) + β-Methyl<1,1'-biphenyl>-4-propansaeure (7320-82-3,71845-02-8,71845-05-1) → β-Methyl<1,1'-biphenyl>-4-propansaeuremethylester (24254-67-9)

Guidance literature:

In diethyl ether; acetone;

Reference yield:

β-Methyl<1,1'-biphenyl>-4-propanenitrile (60106-64-1) → β-Methyl<1,1'-biphenyl>-4-propansaeuremethylester (24254-67-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 65 percent / KOH / various solvent(s) / 6 h / Heating

2: 98 percent / acetone; diethyl ether

With potassium hydroxide; In diethyl ether; acetone;

Reference yield:

biphenyl-4-acetaldehyde (92-91-1) + bromoacetic acid methyl ester (96-32-2) → β-Methyl<1,1'-biphenyl>-4-propansaeuremethylester (24254-67-9)

Guidance literature:

Multistep reaction; (i), (ii) (dehydration), (iii) (hydrogenation);

DOI:10.1039/j29690000439

upstream raw materials:

biphenyl-4-acetaldehyde

bromoacetic acid methyl ester

diazomethane

β-Methyl<1,1'-biphenyl>-4-propansaeure

Refernces