methyl 2-amino-5-(5,5-dimethyl-1,3,2-dioxaborinan-2-yl)benzoate

Base Information

• Chemical Name: methyl 2-amino-5-(5,5-dimethyl-1,3,2-dioxaborinan-2-yl)benzoate
• CAS No.: 872460-04-3
• Molecular Formula: C13H18BNO4
• Molecular Weight: 263.101
• Mol file: 872460-04-3.mol

Synonyms:2-amino-5-(5,5-dimethyl-1,3,2-dioxaborinan-2-yl)-benzoic acid methyl ester;2-amino-5-(5,5-dimethyl-[1,3,2]dioxaborinan-2-yl)-benzoic acid methyl ester;

Chemical Property of methyl 2-amino-5-(5,5-dimethyl-1,3,2-dioxaborinan-2-yl)benzoate

Chemical Property:

• PSA: 70.78000
• LogP: 1.40480

Purity/Quality:

methyl2-amino-5-(5,5-dimethyl-1,3,2-dioxaborinan-2-yl)benzoate 95 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 2-amino-5-(5,5-dimethyl-1,3,2-dioxaborinan-2-yl)benzoate

There total 1 articles about methyl 2-amino-5-(5,5-dimethyl-1,3,2-dioxaborinan-2-yl)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

2-(5,5-dimethyl-1,3,2-dioxaborinan-2-yl)-5,5-dimethyl-1,3,2-dioxaborinane (201733-56-4) + 5-bromo-2-aminobenzoic acid methyl ester (52727-57-8) → methyl 2-amino-5-(5,5-dimethyl- 1,3,2-dioxaborinan- 2-yl)benzoate (872460-04-3)

Guidance literature:

With potassium acetate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In dimethyl sulfoxide; at 80 ℃; for 5h;

Reference yield: 78.0%

methyl 2-amino-5-(5,5-dimethyl- 1,3,2-dioxaborinan- 2-yl)benzoate (872460-04-3) + 2-methyl-2-propanyl{[trans-4-({2-phenyl-1-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2-pyridinyl]ethyl}carbamoyl)cyclohexyl]methyl}carbamate → methyl 2-amino-5-(2-{1-[({trans-4-[({[(2-methyl-2-propanyl)oxy]carbonyl}amino)methyl]cyclohexyl}carbonyl)amino]-2-phenylethyl}-4-pyridinyl)benzoate

Guidance literature:

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; caesium carbonate; tri tert-butylphosphoniumtetrafluoroborate; In 1,4-dioxane; at 20 - 90 ℃; Inert atmosphere; Sealed tube;

DOI:10.1016/j.bmc.2016.03.062

upstream raw materials:

2-(5,5-dimethyl-1,3,2-dioxaborinan-2-yl)-5,5-dimethyl-1,3,2-dioxaborinane

5-bromo-2-aminobenzoic acid methyl ester