Chemical Property of Ro 3306
Chemical Property:
- Boiling Point:569.1±60.0 °C(Predicted)
- PKA:3.99±0.10(Predicted)
- PSA：107.89000
- Density:1.41
- LogP:3.88290
- Storage Temp.:2-8°C
- Solubility.:DMSO: soluble5mg/mL, clear
- Purity/Quality:
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99%, *data from raw suppliers
Ro 3306 *data from reagent suppliers
Safty Information:
- Pictogram(s):
- Hazard Codes:
- MSDS Files:
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SDS file from LookChem
Useful:
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Description
RO-3306 (872573-93-8) is a selective inhibitor of CDK1 (IC50?= 35 nM versus CDK2 IC50?= 340nM).1,2?It induces G2/M phase cell cycle arrest and apoptosis. Inhibition of CDK1 with RO-3306 has been shown to have synergistic effects with PARP inhibitors in treating various breast cancers.3,4?It has also been demonstrated to overcome apoptotic resistance in BRAFV600E?human colorectal cancer cells.5
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Uses
RO-3306 is an ATP-competitive and selective CDK1 inhibitor used against a diverse panel of human kinases. Used in the treatment of malignant tumors in conjunction with PARP inhibitors. RO-3306 has been used:To study the significance of CA4-mediated cytotoxicity in mitotic arrest In cell cycle synchronization to conduct a study on proteomics As a CDK1 inhibitor, to prevent early mitotic entry
