2-Cyclopenten-1-one, 2-(cyclohexylhydroxymethyl)-

Base Information

• Chemical Name: 2-Cyclopenten-1-one, 2-(cyclohexylhydroxymethyl)-
• CAS No.: 872585-01-8
• Molecular Formula: C12H18O2
• Molecular Weight: 194.274
• Mol file: 872585-01-8.mol

Synonyms:

Chemical Property of 2-Cyclopenten-1-one, 2-(cyclohexylhydroxymethyl)-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-Cyclopenten-1-one, 2-(cyclohexylhydroxymethyl)-

There total 1 articles about 2-Cyclopenten-1-one, 2-(cyclohexylhydroxymethyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

cyclopent-2-enone (930-30-3) + cyclohexanecarbaldehyde (2043-61-0) → 2-(1-hydroxycyclohexylmethyl)-2-cyclopenten-1-one (872585-01-8)

Guidance literature:

With dmap; N,N,N,N,-tetramethylethylenediamine; magnesium iodide; In methanol; at 20 ℃; for 48h; Inert atmosphere;

DOI:10.1021/jo900603w

Reference yield: 75.0%

2-(1-hydroxycyclohexylmethyl)-2-cyclopenten-1-one (872585-01-8) + aniline (62-53-3) → 2-[(phenylamino)(cyclohexyl)methyl]cyclopent-2-enone (1156004-27-1)

Guidance literature:

With indium(III) triflate; In tetrahydrofuran; for 12h; regioselective reaction; Molecular sieve; Inert atmosphere; Reflux;

DOI:10.1016/j.tet.2009.02.048

Reference yield: 68.0%

2-(1-hydroxycyclohexylmethyl)-2-cyclopenten-1-one (872585-01-8) + 1-benzylidene-3-oxo-1-pyrazolidinium-2-ide (17822-51-4) → C22H26N2O2

Guidance literature:

With C₂₃H₃₁N₃; (R)-1,1'-binaphthyl-2,2'-phosphoric acid; Thiosalicylic acid; In 1,3,5-trimethyl-benzene; at 50 ℃; for 24h; stereoselective reaction;

DOI:10.1021/acscatal.8b04942

upstream raw materials:

cyclopent-2-enone

cyclohexanecarbaldehyde

Downstream raw materials:

2-[(phenylamino)(cyclohexyl)methyl]cyclopent-2-enone