Benzoic acid, 4-[2-[1-(diphenylmethyl)-2-methyl-5-phenyl-1H-indol-3-yl]ethoxy]-, methyl ester

Base Information

Chemical Name:Benzoic acid, 4-[2-[1-(diphenylmethyl)-2-methyl-5-phenyl-1H-indol-3-yl]ethoxy]-, methyl ester
CAS No.:872675-07-5
Molecular Formula:C38H33NO3
Molecular Weight:551.685
Hs Code.:

Synonyms:

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Chemical Property of Benzoic acid, 4-[2-[1-(diphenylmethyl)-2-methyl-5-phenyl-1H-indol-3-yl]ethoxy]-, methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

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Hazard Codes:

MSDS Files:: SDS file from LookChem

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Technology Process of Benzoic acid, 4-[2-[1-(diphenylmethyl)-2-methyl-5-phenyl-1H-indol-3-yl]ethoxy]-, methyl ester

There total 6 articles about Benzoic acid, 4-[2-[1-(diphenylmethyl)-2-methyl-5-phenyl-1H-indol-3-yl]ethoxy]-, methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 479422-13-4
methyl 4-[2-[5-bromo-1-(diphenylmethyl)-2-methyl-1H-indol-3-yl]ethoxy]benzoate

: 98-80-6
phenylboronic acid

: 872675-07-5
methyl 4-[2-[1-(diphenylmethyl)-2-methyl-5-phenyl-1H-indol-3-yl]ethoxy]benzoate

Guidance literature:: With potassium fluoride; di-tert-butyl(3-phenylphenyl)phosphane; palladium diacetate; In tetrahydrofuran; at 20 ℃; for 24h;
DOI:10.1021/jm0507882

Reference yield:

: 100613-91-0
4-[(4-bromo-phenyl)-hydrazono]-pentanoic acid ethyl ester

: 872675-07-5
methyl 4-[2-[1-(diphenylmethyl)-2-methyl-5-phenyl-1H-indol-3-yl]ethoxy]benzoate

Guidance literature:: Multi-step reaction with 5 steps

1.1: ZnCl₂ / 140 °C

2.1: NaH / dimethylformamide / 0.5 h / 0 °C

2.2: 72 percent / dimethylformamide / 0 - 20 °C

3.1: LiAlH₄ / tetrahydrofuran / 0 °C

4.1: polystyrene-bound PPh₃; diisopropyl azodicarboxylate / CH₂Cl₂

5.1: 65 percent / KF; palladium acetate; (biphenyl-3-yl)di-tert-butylphosphane / tetrahydrofuran / 24 h / 20 °C

With potassium fluoride; lithium aluminium tetrahydride; di-tert-butyl(3-phenylphenyl)phosphane; di-isopropyl azodicarboxylate; polystyrene-bound PPh₃; palladium diacetate; sodium hydride; zinc(II) chloride; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; 1.1: Fisher indole synthesis / 4.1: Mitsunobu reaction / 5.1: Suzuki reaction;
DOI:10.1021/jm0507882

Reference yield:

: 479422-12-3
2-[5-bromo-1-(diphenylmethyl)-2-methyl-1H-indol-3-yl]ethanol

: 872675-07-5
methyl 4-[2-[1-(diphenylmethyl)-2-methyl-5-phenyl-1H-indol-3-yl]ethoxy]benzoate

Guidance literature:: Multi-step reaction with 2 steps

1: polystyrene-bound PPh₃; diisopropyl azodicarboxylate / CH₂Cl₂

2: 65 percent / KF; palladium acetate; (biphenyl-3-yl)di-tert-butylphosphane / tetrahydrofuran / 24 h / 20 °C

With potassium fluoride; di-tert-butyl(3-phenylphenyl)phosphane; di-isopropyl azodicarboxylate; polystyrene-bound PPh₃; palladium diacetate; In tetrahydrofuran; dichloromethane; 1: Mitsunobu reaction / 2: Suzuki reaction;
DOI:10.1021/jm0507882