Technology Process of Benzoic acid,
3-[2-[5-chloro-1-(diphenylmethyl)-2-methyl-1H-indol-3-yl]ethoxy]-, methyl
ester
There total 6 articles about Benzoic acid,
3-[2-[5-chloro-1-(diphenylmethyl)-2-methyl-1H-indol-3-yl]ethoxy]-, methyl
ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
methyl 3-hydroxybenzoate;
With
sodium hydride;
In
dimethyl sulfoxide;
for 0.25h;
3-(2-bromoethyl)-5-chloro-1-(diphenylmethyl)-2-methyl-1H-indole;
In
dimethyl sulfoxide;
at 80 ℃;
for 18h;
DOI:10.1021/jm0507882
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: ZnCl2 / 140 °C
2.1: NaH / dimethylformamide / 0.5 h / 0 °C
2.2: 17 percent / dimethylformamide / 0 - 20 °C
3.1: LiAlH4 / tetrahydrofuran / 0.5 h / 10 °C
4.1: 76 percent / 1,3-bis(diphenylphosphino)propane; carbon tetrabromide / CH2Cl2 / 0 - 20 °C
5.1: NaH / dimethylsulfoxide / 0.25 h
5.2: 23 percent / dimethylsulfoxide / 18 h / 80 °C
With
lithium aluminium tetrahydride; carbon tetrabromide; 1,3-bis-(diphenylphosphino)propane; sodium hydride; zinc(II) chloride;
In
tetrahydrofuran; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide;
1.1: Fisher indole synthesis;
DOI:10.1021/jm0507882
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: 76 percent / 1,3-bis(diphenylphosphino)propane; carbon tetrabromide / CH2Cl2 / 0 - 20 °C
2.1: NaH / dimethylsulfoxide / 0.25 h
2.2: 23 percent / dimethylsulfoxide / 18 h / 80 °C
With
carbon tetrabromide; 1,3-bis-(diphenylphosphino)propane; sodium hydride;
In
dichloromethane; dimethyl sulfoxide;
DOI:10.1021/jm0507882
