2H-Pyran-2-one, 6-[(1E,3S,4R,6R,7Z,9Z,11E)-6-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-13 -[[(1,1-dimethylethyl)diphenylsilyl]oxy]-4-hydroxy-3-methyl-3-[(triethylsilyl) oxy]-1,7,9,11-tridecatetraenyl]-5,6-dihydro-, (6R)-

Base Information

Chemical Name:2H-Pyran-2-one, 6-[(1E,3S,4R,6R,7Z,9Z,11E)-6-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-13 -[[(1,1-dimethylethyl)diphenylsilyl]oxy]-4-hydroxy-3-methyl-3-[(triethylsilyl) oxy]-1,7,9,11-tridecatetraenyl]-5,6-dihydro-, (6R)-
CAS No.:872693-82-8
Molecular Formula:C47H72O6Si3
Molecular Weight:817.342
Hs Code.:

2H-Pyran-2-one,
6-[(1E,3S,4R,6R,7Z,9Z,11E)-6-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-13
-[[(1,1-dimethylethyl)diphenylsilyl]oxy]-4-hydroxy-3-methyl-3-[(triethylsilyl)
oxy]-1,7,9,11-tridecatetraenyl]-5,6-dihydro-, (6R)-

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Suppliers and Price of 2H-Pyran-2-one, 6-[(1E,3S,4R,6R,7Z,9Z,11E)-6-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-13 -[[(1,1-dimethylethyl)diphenylsilyl]oxy]-4-hydroxy-3-methyl-3-[(triethylsilyl) oxy]-1,7,9,11-tridecatetraenyl]-5,6-dihydro-, (6R)-

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Chemical Property of 2H-Pyran-2-one, 6-[(1E,3S,4R,6R,7Z,9Z,11E)-6-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-13 -[[(1,1-dimethylethyl)diphenylsilyl]oxy]-4-hydroxy-3-methyl-3-[(triethylsilyl) oxy]-1,7,9,11-tridecatetraenyl]-5,6-dihydro-, (6R)-

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Technology Process of 2H-Pyran-2-one, 6-[(1E,3S,4R,6R,7Z,9Z,11E)-6-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-13 -[[(1,1-dimethylethyl)diphenylsilyl]oxy]-4-hydroxy-3-methyl-3-[(triethylsilyl) oxy]-1,7,9,11-tridecatetraenyl]-5,6-dihydro-, (6R)-

There total 13 articles about 2H-Pyran-2-one, 6-[(1E,3S,4R,6R,7Z,9Z,11E)-6-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-13 -[[(1,1-dimethylethyl)diphenylsilyl]oxy]-4-hydroxy-3-methyl-3-[(triethylsilyl) oxy]-1,7,9,11-tridecatetraenyl]-5,6-dihydro-, (6R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: (1Z,3E)-5-tert-butyldiphenylsilyloxy-1-tributylstannylpenta-1,3-diene

: (3'R,4'R/S,6R,1'E)-6-(4'-hydroxy-3'-methoxymethoxy-3'-methyl-6'-oxo-8'-trimethylsilyloct-1'-en-7'-ynyl)-5,6-dihydro-pyran-2-one

: 872693-82-8
(3'S,4'R,6'R,6R,1'E,7'Z,9'Z,11'E)-6-(6'-tert-butyldimethylsilyloxy-13-tert-butyldiphenylsilyloxy-4'-hydroxy-3'-methyl-3'-triethylsilyloxy-trideca-1',7',9',11'-tetraenyl)-5,6-dihydropyran-2-one

Guidance literature:: With dichloro bis(acetonitrile) palladium(II); In N,N-dimethyl-formamide; at 40 ℃; for 24h;
DOI:10.1021/ja0562043

Reference yield:

: 503004-58-8
(2R,3E)-5-benzyloxy-2-methyl-pent-3-ene-1,2-diol

: 872693-82-8
(3'S,4'R,6'R,6R,1'E,7'Z,9'Z,11'E)-6-(6'-tert-butyldimethylsilyloxy-13-tert-butyldiphenylsilyloxy-4'-hydroxy-3'-methyl-3'-triethylsilyloxy-trideca-1',7',9',11'-tetraenyl)-5,6-dihydropyran-2-one

Guidance literature:: Multi-step reaction with 11 steps

1: 96 percent / imidazole / dimethylformamide

2: 100 percent / i-Pr₂NEt / CH₂Cl₂

3: 93 percent / Na; NH₃ (liq.) / -78 °C

4: 93 percent / MnO₂ / CH₂Cl₂

5: 80 percent / AgF; (R)-p-Tol-BINAP / methanol / -20 °C

6: 76 percent / Et₃N / CH₂Cl₂

7: 94 percent / Grubb's catalyst 1st generation / CH₂Cl₂

8: 90 percent / Et₃N*3HF / tetrahydrofuran

9: 92 percent / Dess-Martin periodinane / CH₂Cl₂

10: 65 percent / (S)-LLB / tetrahydrofuran / -20 °C

11: 84 percent / PdCl₂(CH₃CN)2 / dimethylformamide / 24 h / 40 °C

With 1H-imidazole; manganese(IV) oxide; dichloro bis(acetonitrile) palladium(II); (S)-lanthanum-lithium-BINOL; (R)-p-Tol-BINAP; ammonia; sodium; silver fluoride; Dess-Martin periodane; triethylamine tris(hydrogen fluoride); triethylamine; N-ethyl-N,N-diisopropylamine; Grubbs catalyst first generation; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; 5: Yamamoto allylation / 11: Stille coupling;
DOI:10.1021/ja0562043

Reference yield:

: 503004-57-7
(2R,3E)-5-benzyloxy-2-methyl-2-trimethylsilyloxypent-3-enenitrile

: 872693-82-8
(3'S,4'R,6'R,6R,1'E,7'Z,9'Z,11'E)-6-(6'-tert-butyldimethylsilyloxy-13-tert-butyldiphenylsilyloxy-4'-hydroxy-3'-methyl-3'-triethylsilyloxy-trideca-1',7',9',11'-tetraenyl)-5,6-dihydropyran-2-one

Guidance literature:: Multi-step reaction with 12 steps

1.1: aq. HCl / ethanol / 60 °C

1.2: NaBH₄ / methanol

2.1: 96 percent / imidazole / dimethylformamide

3.1: 100 percent / i-Pr₂NEt / CH₂Cl₂

4.1: 93 percent / Na; NH₃ (liq.) / -78 °C

5.1: 93 percent / MnO₂ / CH₂Cl₂

6.1: 80 percent / AgF; (R)-p-Tol-BINAP / methanol / -20 °C

7.1: 76 percent / Et₃N / CH₂Cl₂

8.1: 94 percent / Grubb's catalyst 1st generation / CH₂Cl₂

9.1: 90 percent / Et₃N*3HF / tetrahydrofuran

10.1: 92 percent / Dess-Martin periodinane / CH₂Cl₂

11.1: 65 percent / (S)-LLB / tetrahydrofuran / -20 °C

12.1: 84 percent / PdCl₂(CH₃CN)2 / dimethylformamide / 24 h / 40 °C

With 1H-imidazole; hydrogenchloride; manganese(IV) oxide; dichloro bis(acetonitrile) palladium(II); (S)-lanthanum-lithium-BINOL; (R)-p-Tol-BINAP; ammonia; sodium; silver fluoride; Dess-Martin periodane; triethylamine tris(hydrogen fluoride); triethylamine; N-ethyl-N,N-diisopropylamine; Grubbs catalyst first generation; In tetrahydrofuran; methanol; ethanol; dichloromethane; N,N-dimethyl-formamide; 6.1: Yamamoto allylation / 12.1: Stille coupling;
DOI:10.1021/ja0562043