tert-butyl N-[(3-fluoropyrrolidin-3-yl)methyl]carbamate

Base Information

• Chemical Name: tert-butyl N-[(3-fluoropyrrolidin-3-yl)methyl]carbamate
• CAS No.: 872716-26-2
• Molecular Formula: C10H19FN2O2
• Molecular Weight: 218.271
• Mol file: 872716-26-2.mol

Synonyms:TERT-BUTYL (3-FLUOROPYRROLIDIN-3-YL)METHYLCARBAMATE;(+/-)-1,1-dimethylethyl [(3-fluoro-3-pyrrolidinyl)methyl]carbamate;Carbamic acid,[(3-fluoro-3-pyrrolidinyl)methyl]-,1,1-dimethylethyl ester;3-(N-BOC-AMINOMETHYL)-3-FLUOROPYRROLIDINE;

Chemical Property of tert-butyl N-[(3-fluoropyrrolidin-3-yl)methyl]carbamate

Chemical Property:

• PSA: 53.85000
• LogP: 1.74590
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

97% ^*data from raw suppliers

tert-ButylN-[(3-Fluoropyrrolidin-3-yl)methyl]carbamate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: tert-Butyl N-[(3-Fluoropyrrolidin-3-yl)methyl]carbamate is used as a reactant in the synthesis of quinolone derivatives as antibacterials that inhibit bacterial DNA gyrase.

Technology Process of tert-butyl N-[(3-fluoropyrrolidin-3-yl)methyl]carbamate

There total 1 articles about tert-butyl N-[(3-fluoropyrrolidin-3-yl)methyl]carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

(+/-)-phenylmethyl 3-[({[(1,1-dimethylethyl)oxy]carbonyl}amino)methyl]-3-fluoro-1-pyrrolidinecarboxylate (872716-25-1) → tert-butyl N-[(3-fluoropyrrolidin-3-yl)methyl]carbamate (872716-26-2)

Guidance literature:

With hydrogen; palladium dihydroxide; In methanol; at 20 ℃; for 18h; under 760.051 Torr;

Reference yield: 41.0%

tert-butyl N-[(3-fluoropyrrolidin-3-yl)methyl]carbamate (872716-26-2) + ethyl 7-bromo-1-cyclopropyl-6-fluoro-8-methyl-2-oxo-1,2-dihydroquinoline-3-carboxylate → ethyl 7-(3-(((tert-butoxycarbonyl)amino)methyl)-3-fluoropyrrolidin-1-yl)-1-cyclopropyl-6-fluoro-8-methyl-2-oxo-1,2-dihydroquinoline-3-carboxylate

Guidance literature:

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; at 100 ℃; for 6h; Sealed tube;

Reference yield: 35.4%

tert-butyl N-[(3-fluoropyrrolidin-3-yl)methyl]carbamate (872716-26-2) + methyl 4-bromo-2-(N-cyclopropylacetamido)-5,6-difluoro-3-methylbenzoate → methyl 4-(3-(((tert-butoxycarbonyl)amino)methyl)-3-fluoropyrrolidin-1-yl)-2-(N-cyclopropylacetamido)-5,6-difluoro-3-methylbenzoate

Guidance literature:

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; at 130 ℃; for 24h;

upstream raw materials:

(+/-)-phenylmethyl 3-[({[(1,1-dimethylethyl)oxy]carbonyl}amino)methyl]-3-fluoro-1-pyrrolidinecarboxylate

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