1-Piperidinecarboxylic acid, 3-[[(2-methoxyphenyl)methyl]amino]-2-phenyl-, 1,1-dimethylethyl ester, (2R,3R)-

Base Information

Chemical Name:1-Piperidinecarboxylic acid, 3-[[(2-methoxyphenyl)methyl]amino]-2-phenyl-, 1,1-dimethylethyl ester, (2R,3R)-
CAS No.:872726-32-4
Molecular Formula:C24H32N2O3
Molecular Weight:396.53
Hs Code.:

Synonyms:

Suppliers and Price of 1-Piperidinecarboxylic acid, 3-[[(2-methoxyphenyl)methyl]amino]-2-phenyl-, 1,1-dimethylethyl ester, (2R,3R)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 1-Piperidinecarboxylic acid, 3-[[(2-methoxyphenyl)methyl]amino]-2-phenyl-, 1,1-dimethylethyl ester, (2R,3R)-

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 1-Piperidinecarboxylic acid, 3-[[(2-methoxyphenyl)methyl]amino]-2-phenyl-, 1,1-dimethylethyl ester, (2R,3R)-

There total 21 articles about 1-Piperidinecarboxylic acid, 3-[[(2-methoxyphenyl)methyl]amino]-2-phenyl-, 1,1-dimethylethyl ester, (2R,3R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 196080-41-8
methyl (4S)-4,5-bis(t-butyldimethylsilyloxy)pentanoate

: 872726-32-4
(2R,3R)-3-(2-Methoxy-benzylamino)-2-phenyl-piperidine-1-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 10 steps

1.1: CSA / methanol; dichloromethane / 8 h / -40 °C

2.1: Dess-Martin periodane / dichloromethane / 0.5 h / 20 °C

3.1: copper(II) sulfate; pyridinium p-toluenesulfonate / dichloromethane / 24 h

4.1: tetrahydrofuran / 3 h / -78 °C

5.1: lithium aluminium tetrahydride / tetrahydrofuran / 6 h / 60 °C

6.1: triethylamine; sodium hydrogencarbonate / dichloromethane; water / 12 h

7.1: Dess-Martin periodane / dichloromethane / 0.5 h / 20 °C

8.1: pyridine; N-methoxylamine hydrochloride / 0.5 h

9.1: borane / tetrahydrofuran / 4 h / 50 °C

10.1: tetrahydrofuran

10.2: 3 h

With pyridine; lithium aluminium tetrahydride; borane; N-methoxylamine hydrochloride; pyridinium p-toluenesulfonate; sodium hydrogencarbonate; Dess-Martin periodane; copper(II) sulfate; triethylamine; In tetrahydrofuran; methanol; dichloromethane; water;
DOI:10.1021/ol5020812

Reference yield:

: 82065-62-1
methyl (4S)-4-(t-butyldimethylsilyloxy)-5-oxopentanoate

: 872726-32-4
(2R,3R)-3-(2-Methoxy-benzylamino)-2-phenyl-piperidine-1-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 8 steps

1.1: copper(II) sulfate; pyridinium p-toluenesulfonate / dichloromethane / 24 h

2.1: tetrahydrofuran / 3 h / -78 °C

3.1: lithium aluminium tetrahydride / tetrahydrofuran / 6 h / 60 °C

4.1: triethylamine; sodium hydrogencarbonate / dichloromethane; water / 12 h

5.1: Dess-Martin periodane / dichloromethane / 0.5 h / 20 °C

6.1: pyridine; N-methoxylamine hydrochloride / 0.5 h

7.1: borane / tetrahydrofuran / 4 h / 50 °C

8.1: tetrahydrofuran

8.2: 3 h

With pyridine; lithium aluminium tetrahydride; borane; N-methoxylamine hydrochloride; pyridinium p-toluenesulfonate; sodium hydrogencarbonate; Dess-Martin periodane; copper(II) sulfate; triethylamine; In tetrahydrofuran; dichloromethane; water;
DOI:10.1021/ol5020812

Reference yield:

: 89245-23-8
methyl (4S)-4-(t-butyldimethylsilyloxy)-5-hydroxypentanoate

: 872726-32-4
(2R,3R)-3-(2-Methoxy-benzylamino)-2-phenyl-piperidine-1-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 9 steps

1.1: Dess-Martin periodane / dichloromethane / 0.5 h / 20 °C

2.1: copper(II) sulfate; pyridinium p-toluenesulfonate / dichloromethane / 24 h

3.1: tetrahydrofuran / 3 h / -78 °C

4.1: lithium aluminium tetrahydride / tetrahydrofuran / 6 h / 60 °C

5.1: triethylamine; sodium hydrogencarbonate / dichloromethane; water / 12 h

6.1: Dess-Martin periodane / dichloromethane / 0.5 h / 20 °C

7.1: pyridine; N-methoxylamine hydrochloride / 0.5 h

8.1: borane / tetrahydrofuran / 4 h / 50 °C

9.1: tetrahydrofuran

9.2: 3 h

With pyridine; lithium aluminium tetrahydride; borane; N-methoxylamine hydrochloride; pyridinium p-toluenesulfonate; sodium hydrogencarbonate; Dess-Martin periodane; copper(II) sulfate; triethylamine; In tetrahydrofuran; dichloromethane; water;
DOI:10.1021/ol5020812