Cyclohexanecarboxamide, N-[2-[[12-[(6-chloro-2-methoxy-9-acridinyl)amino]-1-oxododecyl]amino] ethyl]-4-[(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)methyl]-

Base Information

Chemical Name:Cyclohexanecarboxamide, N-[2-[[12-[(6-chloro-2-methoxy-9-acridinyl)amino]-1-oxododecyl]amino] ethyl]-4-[(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)methyl]-
CAS No.:872854-08-5
Molecular Formula:C40H52ClN5O5
Molecular Weight:718.336
Hs Code.:

Cyclohexanecarboxamide,
N-[2-[[12-[(6-chloro-2-methoxy-9-acridinyl)amino]-1-oxododecyl]amino]
ethyl]-4-[(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)methyl]-

Synonyms:

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Cyclohexanecarboxamide, N-[2-[[12-[(6-chloro-2-methoxy-9-acridinyl)amino]-1-oxododecyl]amino] ethyl]-4-[(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)methyl]-

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of Cyclohexanecarboxamide, N-[2-[[12-[(6-chloro-2-methoxy-9-acridinyl)amino]-1-oxododecyl]amino] ethyl]-4-[(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)methyl]-

There total 7 articles about Cyclohexanecarboxamide, N-[2-[[12-[(6-chloro-2-methoxy-9-acridinyl)amino]-1-oxododecyl]amino] ethyl]-4-[(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)methyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 872854-06-3
12-(6-chloro-2-methoxy-acridin-9-ylamino)-dodecanoic acid (2-amino-ethyl)-amide

: 64987-85-5
4-(N-maleimidomethyl)cyclohexane-1-carboxylic acid N-succinimidyl ester

: 872854-08-5
4-(2,5-dioxo-2,5-dihydro-pyrrol-1-yl-methyl)-cyclohexanecarboxylic acid {2-[12-(6-chloro-2-methoxy-acridin-9-ylamino)-dodecanoylamino]-ethyl}-amide

Guidance literature:: With triethylamine; In N,N-dimethyl-formamide; at 20 ℃;
DOI:10.1016/j.ejmech.2005.07.015

Reference yield:

: 139270-93-2
N-(allyloxycarbonyl)-12-aminododecanoic acid

: 872854-08-5
4-(2,5-dioxo-2,5-dihydro-pyrrol-1-yl-methyl)-cyclohexanecarboxylic acid {2-[12-(6-chloro-2-methoxy-acridin-9-ylamino)-dodecanoylamino]-ethyl}-amide

Guidance literature:: Multi-step reaction with 5 steps

1: 75 percent / triethylamine; 1-hydroxybenzotriazole; N-ethyl-N'-(3-dimethylaminopropyl)-carbodiimide / dimethylformamide / 24 h / 20 °C

2: 70 percent / diethylamine; tetrakis(triphenylphosphine)palladium / CH₂Cl₂ / 2 h / 20 °C

3: 76 percent / 4-methylmorpholine; phenol / 2 h / 100 °C

4: 100 percent / trifluoroacetic acid / CH₂Cl₂ / 1 h / 20 °C

5: 84 percent / triethylamine / dimethylformamide / 20 °C

With 4-methyl-morpholine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; diethylamine; triethylamine; trifluoroacetic acid; phenol; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.ejmech.2005.07.015

Reference yield:

: 872853-99-1
[2-(12-aminododecanoyl)amino-ethyl]-carbamic acid tert-butyl ester

: 872854-08-5
4-(2,5-dioxo-2,5-dihydro-pyrrol-1-yl-methyl)-cyclohexanecarboxylic acid {2-[12-(6-chloro-2-methoxy-acridin-9-ylamino)-dodecanoylamino]-ethyl}-amide

Guidance literature:: Multi-step reaction with 3 steps

1: 76 percent / 4-methylmorpholine; phenol / 2 h / 100 °C

2: 100 percent / trifluoroacetic acid / CH₂Cl₂ / 1 h / 20 °C

3: 84 percent / triethylamine / dimethylformamide / 20 °C

With 4-methyl-morpholine; triethylamine; trifluoroacetic acid; phenol; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.ejmech.2005.07.015