Technology Process of Benzeneacetamide,
N-[1-[(3R)-3-(3,5-difluorophenyl)-3-[1-(methylsulfonyl)-4-piperidinyl]prop
yl]-4-piperidinyl]-N-ethyl-4-(methylsulfonyl)-
There total 7 articles about Benzeneacetamide,
N-[1-[(3R)-3-(3,5-difluorophenyl)-3-[1-(methylsulfonyl)-4-piperidinyl]prop
yl]-4-piperidinyl]-N-ethyl-4-(methylsulfonyl)- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
(R)-iso-propyl 3-(3,5-difluorophenyl)-3-(1-(methylsulfonyl)piperidine-4-yl)propanoate;
With
diisobutylaluminium hydride;
In
tetrahydrofuran;
at -10 - -5 ℃;
With
hydrogenchloride; sodium chloride;
In
tetrahydrofuran; water;
at 35 ℃;
N-ethyl-2-(4-methanesulfonyl-phenyl)-N-piperidin-4-yl-acetamide;
With
succinic acid; potassium carbonate; triethylamine; p-toluenesulfonyl chloride;
trimethylamine hydrochloride;
more than 3 stages;
- Guidance literature:
-
With
sodium tris(acetoxy)borohydride;
In
dichloromethane;
for 2h;
- Guidance literature:
-
Multi-step reaction with 2 steps
1: Dess-Martin periodane / dichloromethane / 20 °C
2: sodium tris(acetoxy)borohydride / dichloromethane / 20 °C
With
sodium tris(acetoxy)borohydride; Dess-Martin periodane;
In
dichloromethane;
DOI:10.1016/j.bmcl.2011.12.117
